Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins

We recently found that toxic PS-ASOs can cause P54nrb and PSF nucleolar mislocalization in an RNase H1-dependent manner. To better understand the underlying mechanisms of these observations, here we utilize different biochemical approaches to demonstrate that PS-ASO binding can alter the conformatio...

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Detalles Bibliográficos
Autores principales: Zhang, Lingdi, Vickers, Timothy A, Sun, Hong, Liang, Xue-hai, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969025/
https://www.ncbi.nlm.nih.gov/pubmed/33577678
http://dx.doi.org/10.1093/nar/gkab078

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