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Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population

BACKGROUND/AIMS: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine that acts on the muscle and liver affecting insulin s...

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Autores principales: Kim, Byung-Keun, Song, Woo-Jung, Seo, Bomi, Kim, Ju-Young, Kim, Sae-Hoon, Jang, Hak C., Kim, Ki-Woong, Chang, Yoon-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969066/
https://www.ncbi.nlm.nih.gov/pubmed/33045798
http://dx.doi.org/10.3904/kjim.2019.348
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author Kim, Byung-Keun
Song, Woo-Jung
Seo, Bomi
Kim, Ju-Young
Kim, Sae-Hoon
Jang, Hak C.
Kim, Ki-Woong
Chang, Yoon-Seok
author_facet Kim, Byung-Keun
Song, Woo-Jung
Seo, Bomi
Kim, Ju-Young
Kim, Sae-Hoon
Jang, Hak C.
Kim, Ki-Woong
Chang, Yoon-Seok
author_sort Kim, Byung-Keun
collection PubMed
description BACKGROUND/AIMS: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine that acts on the muscle and liver affecting insulin sensitivity. We evaluated the association between metabolic parameters and allergic sensitization in the elderly. METHODS: We analysed the database of the Korean Longitudinal Study on Health and Aging cohort study conducted during 2005 to 2006. Atopy was identified by inhalant allergen skin prick test. Metabolic conditions were assessed using anthropometric indices and serum biomarkers such as fasting glucose, lipid, adiponectin, and RBP-4. RESULTS: Among the 854 elderly subjects, 17.2% had atopy. Plasma RBP-4 levels were significantly higher in the atopic elderly than nonatopic elderly (p = 0.003). When RBP-4 percentiles were categorized as under three groups, the prevalence of atopy and current rhinitis increased significantly with percentiles of RBP-4 levels (p = 0.019 and p = 0.007, respectively). Log RBP-4 was associated with atopy (odds ratio [OR], 4.10; p = 0.009) and current rhinitis (OR, 2.73; p = 0.014), but not with current asthma (OR, 1.17; p = 0.824). Higher RBP-4 level in atopic elderly was also observed in current rhinitis patients. Atopy, but not current rhinitis, showed significant relationships with log RBP-4 levels in multivariate analyses adjusted for other metabolic markers including body mass index. CONCLUSIONS: RBP-4 positively associated with atopy in the general elderly population irrespective of other metabolic markers.
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spelling pubmed-79690662021-04-01 Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population Kim, Byung-Keun Song, Woo-Jung Seo, Bomi Kim, Ju-Young Kim, Sae-Hoon Jang, Hak C. Kim, Ki-Woong Chang, Yoon-Seok Korean J Intern Med Original Article BACKGROUND/AIMS: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine that acts on the muscle and liver affecting insulin sensitivity. We evaluated the association between metabolic parameters and allergic sensitization in the elderly. METHODS: We analysed the database of the Korean Longitudinal Study on Health and Aging cohort study conducted during 2005 to 2006. Atopy was identified by inhalant allergen skin prick test. Metabolic conditions were assessed using anthropometric indices and serum biomarkers such as fasting glucose, lipid, adiponectin, and RBP-4. RESULTS: Among the 854 elderly subjects, 17.2% had atopy. Plasma RBP-4 levels were significantly higher in the atopic elderly than nonatopic elderly (p = 0.003). When RBP-4 percentiles were categorized as under three groups, the prevalence of atopy and current rhinitis increased significantly with percentiles of RBP-4 levels (p = 0.019 and p = 0.007, respectively). Log RBP-4 was associated with atopy (odds ratio [OR], 4.10; p = 0.009) and current rhinitis (OR, 2.73; p = 0.014), but not with current asthma (OR, 1.17; p = 0.824). Higher RBP-4 level in atopic elderly was also observed in current rhinitis patients. Atopy, but not current rhinitis, showed significant relationships with log RBP-4 levels in multivariate analyses adjusted for other metabolic markers including body mass index. CONCLUSIONS: RBP-4 positively associated with atopy in the general elderly population irrespective of other metabolic markers. The Korean Association of Internal Medicine 2021-03 2020-10-13 /pmc/articles/PMC7969066/ /pubmed/33045798 http://dx.doi.org/10.3904/kjim.2019.348 Text en Copyright © 2021 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Byung-Keun
Song, Woo-Jung
Seo, Bomi
Kim, Ju-Young
Kim, Sae-Hoon
Jang, Hak C.
Kim, Ki-Woong
Chang, Yoon-Seok
Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population
title Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population
title_full Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population
title_fullStr Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population
title_full_unstemmed Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population
title_short Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population
title_sort retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969066/
https://www.ncbi.nlm.nih.gov/pubmed/33045798
http://dx.doi.org/10.3904/kjim.2019.348
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