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The Silva Pattern-based Classification for HPV-associated Invasive Endocervical Adenocarcinoma and the Distinction Between In Situ and Invasive Adenocarcinoma: Relevant Issues and Recommendations From the International Society of Gynecological Pathologists

The Silva pattern-based classification for human papilloma virus–associated invasive adenocarcinoma has emerged as a reliable system to predict risk of lymph node metastasis and recurrences. Although not a part of any staging system yet, it has been incorporated in synoptic reports as established by...

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Autores principales: Alvarado-Cabrero, Isabel, Parra-Herran, Carlos, Stolnicu, Simona, Roma, Andres, Oliva, Esther, Malpica, Anais
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969170/
https://www.ncbi.nlm.nih.gov/pubmed/33570863
http://dx.doi.org/10.1097/PGP.0000000000000735
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author Alvarado-Cabrero, Isabel
Parra-Herran, Carlos
Stolnicu, Simona
Roma, Andres
Oliva, Esther
Malpica, Anais
author_facet Alvarado-Cabrero, Isabel
Parra-Herran, Carlos
Stolnicu, Simona
Roma, Andres
Oliva, Esther
Malpica, Anais
author_sort Alvarado-Cabrero, Isabel
collection PubMed
description The Silva pattern-based classification for human papilloma virus–associated invasive adenocarcinoma has emerged as a reliable system to predict risk of lymph node metastasis and recurrences. Although not a part of any staging system yet, it has been incorporated in synoptic reports as established by the College of American Pathologists (CAP) and the International Collaboration on Cancer Reporting (ICCR). Moreover, the current National Comprehensive Cancer Network (NCCN) guidelines include this classification as an “emergent concept.” In order to facilitate the understating and application of this new classification by all pathologists, the ISGyP Endocervical Adenocarcinoma Project Working Group presents herein all the current evidence on the Silva classification and aims to provide recommendations for its implementation in practice, including interpretation, reporting, and application to biopsy and resection specimens. In addition, this article addresses the distinction of human papilloma virus–associated adenocarcinoma in situ and gastric type adenocarcinoma in situ from their invasive counterparts.
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spelling pubmed-79691702021-03-29 The Silva Pattern-based Classification for HPV-associated Invasive Endocervical Adenocarcinoma and the Distinction Between In Situ and Invasive Adenocarcinoma: Relevant Issues and Recommendations From the International Society of Gynecological Pathologists Alvarado-Cabrero, Isabel Parra-Herran, Carlos Stolnicu, Simona Roma, Andres Oliva, Esther Malpica, Anais Int J Gynecol Pathol Articles The Silva pattern-based classification for human papilloma virus–associated invasive adenocarcinoma has emerged as a reliable system to predict risk of lymph node metastasis and recurrences. Although not a part of any staging system yet, it has been incorporated in synoptic reports as established by the College of American Pathologists (CAP) and the International Collaboration on Cancer Reporting (ICCR). Moreover, the current National Comprehensive Cancer Network (NCCN) guidelines include this classification as an “emergent concept.” In order to facilitate the understating and application of this new classification by all pathologists, the ISGyP Endocervical Adenocarcinoma Project Working Group presents herein all the current evidence on the Silva classification and aims to provide recommendations for its implementation in practice, including interpretation, reporting, and application to biopsy and resection specimens. In addition, this article addresses the distinction of human papilloma virus–associated adenocarcinoma in situ and gastric type adenocarcinoma in situ from their invasive counterparts. Lippincott Williams & Wilkins 2021-03 2021-02-09 /pmc/articles/PMC7969170/ /pubmed/33570863 http://dx.doi.org/10.1097/PGP.0000000000000735 Text en Copyright © 2021 International Society of Gynecological Pathologists. Published by Wolters Kluwer Health, Inc. on behalf of the International Society of Gynecological Pathologists. This is an open access article distributed under the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/) (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
spellingShingle Articles
Alvarado-Cabrero, Isabel
Parra-Herran, Carlos
Stolnicu, Simona
Roma, Andres
Oliva, Esther
Malpica, Anais
The Silva Pattern-based Classification for HPV-associated Invasive Endocervical Adenocarcinoma and the Distinction Between In Situ and Invasive Adenocarcinoma: Relevant Issues and Recommendations From the International Society of Gynecological Pathologists
title The Silva Pattern-based Classification for HPV-associated Invasive Endocervical Adenocarcinoma and the Distinction Between In Situ and Invasive Adenocarcinoma: Relevant Issues and Recommendations From the International Society of Gynecological Pathologists
title_full The Silva Pattern-based Classification for HPV-associated Invasive Endocervical Adenocarcinoma and the Distinction Between In Situ and Invasive Adenocarcinoma: Relevant Issues and Recommendations From the International Society of Gynecological Pathologists
title_fullStr The Silva Pattern-based Classification for HPV-associated Invasive Endocervical Adenocarcinoma and the Distinction Between In Situ and Invasive Adenocarcinoma: Relevant Issues and Recommendations From the International Society of Gynecological Pathologists
title_full_unstemmed The Silva Pattern-based Classification for HPV-associated Invasive Endocervical Adenocarcinoma and the Distinction Between In Situ and Invasive Adenocarcinoma: Relevant Issues and Recommendations From the International Society of Gynecological Pathologists
title_short The Silva Pattern-based Classification for HPV-associated Invasive Endocervical Adenocarcinoma and the Distinction Between In Situ and Invasive Adenocarcinoma: Relevant Issues and Recommendations From the International Society of Gynecological Pathologists
title_sort silva pattern-based classification for hpv-associated invasive endocervical adenocarcinoma and the distinction between in situ and invasive adenocarcinoma: relevant issues and recommendations from the international society of gynecological pathologists
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969170/
https://www.ncbi.nlm.nih.gov/pubmed/33570863
http://dx.doi.org/10.1097/PGP.0000000000000735
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