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p-STAT3 expression in breast cancer correlates negatively with tumor size and HER2 status

Although some studies have reported the expression and clinical significance of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in breast cancer tissues, it is still controversial whether p-STAT3 play a role in promoting or suppressing cancer. Here, we used immunohistoche...

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Autores principales: Wang, Yan, Wang, Qian, Tang, Chih-Hsin, Chen, Hua-Dong, Hu, Gui-Nv, Shao, Jun-Kang, Dong, Xiao-Fang, Jin, Lu-Lu, Wang, Chao-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969220/
https://www.ncbi.nlm.nih.gov/pubmed/33725911
http://dx.doi.org/10.1097/MD.0000000000025124
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author Wang, Yan
Wang, Qian
Tang, Chih-Hsin
Chen, Hua-Dong
Hu, Gui-Nv
Shao, Jun-Kang
Dong, Xiao-Fang
Jin, Lu-Lu
Wang, Chao-Qun
author_facet Wang, Yan
Wang, Qian
Tang, Chih-Hsin
Chen, Hua-Dong
Hu, Gui-Nv
Shao, Jun-Kang
Dong, Xiao-Fang
Jin, Lu-Lu
Wang, Chao-Qun
author_sort Wang, Yan
collection PubMed
description Although some studies have reported the expression and clinical significance of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in breast cancer tissues, it is still controversial whether p-STAT3 play a role in promoting or suppressing cancer. Here, we used immunohistochemistry analysis to explore expression of p-STAT3 in 407 cases of breast cancer, and analyzed the relationship between p-STAT3 expression and the clinicopathological characteristics and prognosis of breast cancer patients. Positive p-STAT3 expression was seen in 112 cases (27.5%) of breast cancer. p-STAT3 expression was negatively correlated with tumor size, tumor stage and human epidermal growth factor receptor 2 (HER2) status, and the positive rate of p-STAT3 was lowest in HER2-enriched subtype breast cancer (15.3%), while other subtypes were luminal B (23.0%), luminal A (30.2%), and triple-negative breast cancer (TNBC) (37.5%). Logistic regression model multivariate analysis showed that the independent correlation factor of p-STAT3 expression in breast cancer was tumor size (OR = 0.187, 95% CI = 0.042–0.839, P = .029) and HER2 status (OR = 0.392, 95% CI = 0.216–0.710, P = .002). In this study, no clear relationship was observed between patients’ prognosis and expression of p-STAT3. Therefore, we suggest that p-STAT3 expression in breast cancer is negatively correlated with tumor size and HER2 status, but appears to have no effect on survival.
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spelling pubmed-79692202021-03-18 p-STAT3 expression in breast cancer correlates negatively with tumor size and HER2 status Wang, Yan Wang, Qian Tang, Chih-Hsin Chen, Hua-Dong Hu, Gui-Nv Shao, Jun-Kang Dong, Xiao-Fang Jin, Lu-Lu Wang, Chao-Qun Medicine (Baltimore) 5700 Although some studies have reported the expression and clinical significance of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in breast cancer tissues, it is still controversial whether p-STAT3 play a role in promoting or suppressing cancer. Here, we used immunohistochemistry analysis to explore expression of p-STAT3 in 407 cases of breast cancer, and analyzed the relationship between p-STAT3 expression and the clinicopathological characteristics and prognosis of breast cancer patients. Positive p-STAT3 expression was seen in 112 cases (27.5%) of breast cancer. p-STAT3 expression was negatively correlated with tumor size, tumor stage and human epidermal growth factor receptor 2 (HER2) status, and the positive rate of p-STAT3 was lowest in HER2-enriched subtype breast cancer (15.3%), while other subtypes were luminal B (23.0%), luminal A (30.2%), and triple-negative breast cancer (TNBC) (37.5%). Logistic regression model multivariate analysis showed that the independent correlation factor of p-STAT3 expression in breast cancer was tumor size (OR = 0.187, 95% CI = 0.042–0.839, P = .029) and HER2 status (OR = 0.392, 95% CI = 0.216–0.710, P = .002). In this study, no clear relationship was observed between patients’ prognosis and expression of p-STAT3. Therefore, we suggest that p-STAT3 expression in breast cancer is negatively correlated with tumor size and HER2 status, but appears to have no effect on survival. Lippincott Williams & Wilkins 2021-03-12 /pmc/articles/PMC7969220/ /pubmed/33725911 http://dx.doi.org/10.1097/MD.0000000000025124 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5700
Wang, Yan
Wang, Qian
Tang, Chih-Hsin
Chen, Hua-Dong
Hu, Gui-Nv
Shao, Jun-Kang
Dong, Xiao-Fang
Jin, Lu-Lu
Wang, Chao-Qun
p-STAT3 expression in breast cancer correlates negatively with tumor size and HER2 status
title p-STAT3 expression in breast cancer correlates negatively with tumor size and HER2 status
title_full p-STAT3 expression in breast cancer correlates negatively with tumor size and HER2 status
title_fullStr p-STAT3 expression in breast cancer correlates negatively with tumor size and HER2 status
title_full_unstemmed p-STAT3 expression in breast cancer correlates negatively with tumor size and HER2 status
title_short p-STAT3 expression in breast cancer correlates negatively with tumor size and HER2 status
title_sort p-stat3 expression in breast cancer correlates negatively with tumor size and her2 status
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969220/
https://www.ncbi.nlm.nih.gov/pubmed/33725911
http://dx.doi.org/10.1097/MD.0000000000025124
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