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Effectiveness and safety of electroacupuncture in treating Parkinson disease: A protocol for systematic review and meta-analyses
BACKGROUND: Parkinson disease (PD) is an Extrapyramidal Disease mainly characterized by static tremor, myotonia, bradykinesia and postural gait disorder. As China's population ages, the number of people suffering from PD is increasing. Since there are many side effects of western medicine for P...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969292/ https://www.ncbi.nlm.nih.gov/pubmed/33725902 http://dx.doi.org/10.1097/MD.0000000000025095 |
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author | Xu, Wei OuYang, Sha Chi, Zhenhai Wang, ZhiQin Zhu, DaoCheng Chen, RiXin Zhong, GenPing Zhang, FengTing Zhou, GuiQin Duan, SiWei Jiao, Lin |
author_facet | Xu, Wei OuYang, Sha Chi, Zhenhai Wang, ZhiQin Zhu, DaoCheng Chen, RiXin Zhong, GenPing Zhang, FengTing Zhou, GuiQin Duan, SiWei Jiao, Lin |
author_sort | Xu, Wei |
collection | PubMed |
description | BACKGROUND: Parkinson disease (PD) is an Extrapyramidal Disease mainly characterized by static tremor, myotonia, bradykinesia and postural gait disorder. As China's population ages, the number of people suffering from PD is increasing. Since there are many side effects of western medicine for Parkinson's patients, and the high price of the drugs make it difficult for many patients to adhere to treat. At present, many clinical studies have shown that electroacupuncture is effective in treating PD. Therefore, this systematic review aims to explore the effectiveness and safety of electroacupuncture in the treatment of PD. METHODS: Comprehensive search of PubMed, Embase, Medline, Cochrane Database of Systematic Reviews, Chinese Biomedical Literatures Database, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wang Fang Database from inception to February 2021, the literature selected is not restricted by language. In addition, we will search for unpublished studies and the references that were originally included in the literature manually. There were two reviewers screened the data and cross-checked the information individually, the quality of the literature was assessed by reviewers independently. The outcomes of interest include:the scale of Unifified PD Rating Scales, the Webster scale, the Quality of Life Questionnaire, total effective rate, recurrence rate, adverse events. The laboratory inspection indicators include:the content of lipid peroxidase, Superoxide dismutase activity in plasma and erythrocyte. The relevant randomized controlled trials will be included in this study. And we will evaluate the quality of the selected literature according to the Cochrane Handbook. Meta-analysis will be performed using RevMan 5.4.0 software. The heterogeneity test will be implemented in the included literature, the tests’ thresholds will be P < .1 and I(2) > 50%. We will use either fixed effects model or random effects model according to the size of heterogeneity. RESULTS: The results of this systematic review will provide a comprehensive evidence for the clinical treatment of PD, and we will report this result soon. CONCLUSION: This paper will explore whether or not electroacupuncture can be used as a non-drug therapy for PD. ETHICS AND DISSEMINATION: Ethical approval is not required for this paper, our plan will be published in the journal. TRIAL REGISTRATION NUMBER: INPLASY202120031 |
format | Online Article Text |
id | pubmed-7969292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-79692922021-03-18 Effectiveness and safety of electroacupuncture in treating Parkinson disease: A protocol for systematic review and meta-analyses Xu, Wei OuYang, Sha Chi, Zhenhai Wang, ZhiQin Zhu, DaoCheng Chen, RiXin Zhong, GenPing Zhang, FengTing Zhou, GuiQin Duan, SiWei Jiao, Lin Medicine (Baltimore) 3800 BACKGROUND: Parkinson disease (PD) is an Extrapyramidal Disease mainly characterized by static tremor, myotonia, bradykinesia and postural gait disorder. As China's population ages, the number of people suffering from PD is increasing. Since there are many side effects of western medicine for Parkinson's patients, and the high price of the drugs make it difficult for many patients to adhere to treat. At present, many clinical studies have shown that electroacupuncture is effective in treating PD. Therefore, this systematic review aims to explore the effectiveness and safety of electroacupuncture in the treatment of PD. METHODS: Comprehensive search of PubMed, Embase, Medline, Cochrane Database of Systematic Reviews, Chinese Biomedical Literatures Database, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wang Fang Database from inception to February 2021, the literature selected is not restricted by language. In addition, we will search for unpublished studies and the references that were originally included in the literature manually. There were two reviewers screened the data and cross-checked the information individually, the quality of the literature was assessed by reviewers independently. The outcomes of interest include:the scale of Unifified PD Rating Scales, the Webster scale, the Quality of Life Questionnaire, total effective rate, recurrence rate, adverse events. The laboratory inspection indicators include:the content of lipid peroxidase, Superoxide dismutase activity in plasma and erythrocyte. The relevant randomized controlled trials will be included in this study. And we will evaluate the quality of the selected literature according to the Cochrane Handbook. Meta-analysis will be performed using RevMan 5.4.0 software. The heterogeneity test will be implemented in the included literature, the tests’ thresholds will be P < .1 and I(2) > 50%. We will use either fixed effects model or random effects model according to the size of heterogeneity. RESULTS: The results of this systematic review will provide a comprehensive evidence for the clinical treatment of PD, and we will report this result soon. CONCLUSION: This paper will explore whether or not electroacupuncture can be used as a non-drug therapy for PD. ETHICS AND DISSEMINATION: Ethical approval is not required for this paper, our plan will be published in the journal. TRIAL REGISTRATION NUMBER: INPLASY202120031 Lippincott Williams & Wilkins 2021-03-12 /pmc/articles/PMC7969292/ /pubmed/33725902 http://dx.doi.org/10.1097/MD.0000000000025095 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 3800 Xu, Wei OuYang, Sha Chi, Zhenhai Wang, ZhiQin Zhu, DaoCheng Chen, RiXin Zhong, GenPing Zhang, FengTing Zhou, GuiQin Duan, SiWei Jiao, Lin Effectiveness and safety of electroacupuncture in treating Parkinson disease: A protocol for systematic review and meta-analyses |
title | Effectiveness and safety of electroacupuncture in treating Parkinson disease: A protocol for systematic review and meta-analyses |
title_full | Effectiveness and safety of electroacupuncture in treating Parkinson disease: A protocol for systematic review and meta-analyses |
title_fullStr | Effectiveness and safety of electroacupuncture in treating Parkinson disease: A protocol for systematic review and meta-analyses |
title_full_unstemmed | Effectiveness and safety of electroacupuncture in treating Parkinson disease: A protocol for systematic review and meta-analyses |
title_short | Effectiveness and safety of electroacupuncture in treating Parkinson disease: A protocol for systematic review and meta-analyses |
title_sort | effectiveness and safety of electroacupuncture in treating parkinson disease: a protocol for systematic review and meta-analyses |
topic | 3800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969292/ https://www.ncbi.nlm.nih.gov/pubmed/33725902 http://dx.doi.org/10.1097/MD.0000000000025095 |
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