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Chinese herbal compounds containing scorpion in the treatment of epilepsy: A protocol for systematic review and meta-analysis

BACKGROUND: Epilepsy is 1 of the common neurodevelopmental diseases. It can affect about 0.5% to 1.0% of the population regardless of their race and social class. Despite the development of a wide range of treatments, there remaining about one-third of patients still experience seizures. Chinese her...

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Autores principales: Rong, Ping, Fu, Qianfang, Zhang, Xilian, Liu, Xuan, Yang, Jie, Wang, Xin, Wang, Shuai, Liu, Hui, Ma, Rong, Nie, Lianghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969296/
https://www.ncbi.nlm.nih.gov/pubmed/33725915
http://dx.doi.org/10.1097/MD.0000000000025134
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author Rong, Ping
Fu, Qianfang
Zhang, Xilian
Liu, Xuan
Yang, Jie
Wang, Xin
Wang, Shuai
Liu, Hui
Ma, Rong
Nie, Lianghui
Ma, Rong
author_facet Rong, Ping
Fu, Qianfang
Zhang, Xilian
Liu, Xuan
Yang, Jie
Wang, Xin
Wang, Shuai
Liu, Hui
Ma, Rong
Nie, Lianghui
Ma, Rong
author_sort Rong, Ping
collection PubMed
description BACKGROUND: Epilepsy is 1 of the common neurodevelopmental diseases. It can affect about 0.5% to 1.0% of the population regardless of their race and social class. Despite the development of a wide range of treatments, there remaining about one-third of patients still experience seizures. Chinese herbal compounds containing scorpion (CHCCS) have shown an outstanding curative effect on nerve protection and epilepsy. But there's no study to assess its clinical efficacy and safety. METHODS: Each data of CHCCS in treating epilepsy from related English and Chinese databases will be searched. The primary outcome is the efficacy of the CHCCS on epilepsy. And the secondary outcomes include recurrence rate and side effects. The risk of bias will be assessed, and RevMan5.3 and Stata14.0 will be performed for meta-analysis. Finally, we will assess the level of the resulting evidence. RESULTS: The results of the study will be combined with current evidence and published in a peer-reviewed journal. CONCLUSIONS: This study will specifically investigate the effectiveness and safety of CHCCS in treating epilepsy. INPLASY REGISTRATION NUMBER: INPLASY202120056.
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spelling pubmed-79692962021-03-18 Chinese herbal compounds containing scorpion in the treatment of epilepsy: A protocol for systematic review and meta-analysis Rong, Ping Fu, Qianfang Zhang, Xilian Liu, Xuan Yang, Jie Wang, Xin Wang, Shuai Liu, Hui Ma, Rong Nie, Lianghui Ma, Rong Medicine (Baltimore) 3800 BACKGROUND: Epilepsy is 1 of the common neurodevelopmental diseases. It can affect about 0.5% to 1.0% of the population regardless of their race and social class. Despite the development of a wide range of treatments, there remaining about one-third of patients still experience seizures. Chinese herbal compounds containing scorpion (CHCCS) have shown an outstanding curative effect on nerve protection and epilepsy. But there's no study to assess its clinical efficacy and safety. METHODS: Each data of CHCCS in treating epilepsy from related English and Chinese databases will be searched. The primary outcome is the efficacy of the CHCCS on epilepsy. And the secondary outcomes include recurrence rate and side effects. The risk of bias will be assessed, and RevMan5.3 and Stata14.0 will be performed for meta-analysis. Finally, we will assess the level of the resulting evidence. RESULTS: The results of the study will be combined with current evidence and published in a peer-reviewed journal. CONCLUSIONS: This study will specifically investigate the effectiveness and safety of CHCCS in treating epilepsy. INPLASY REGISTRATION NUMBER: INPLASY202120056. Lippincott Williams & Wilkins 2021-03-12 /pmc/articles/PMC7969296/ /pubmed/33725915 http://dx.doi.org/10.1097/MD.0000000000025134 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 3800
Rong, Ping
Fu, Qianfang
Zhang, Xilian
Liu, Xuan
Yang, Jie
Wang, Xin
Wang, Shuai
Liu, Hui
Ma, Rong
Nie, Lianghui
Ma, Rong
Chinese herbal compounds containing scorpion in the treatment of epilepsy: A protocol for systematic review and meta-analysis
title Chinese herbal compounds containing scorpion in the treatment of epilepsy: A protocol for systematic review and meta-analysis
title_full Chinese herbal compounds containing scorpion in the treatment of epilepsy: A protocol for systematic review and meta-analysis
title_fullStr Chinese herbal compounds containing scorpion in the treatment of epilepsy: A protocol for systematic review and meta-analysis
title_full_unstemmed Chinese herbal compounds containing scorpion in the treatment of epilepsy: A protocol for systematic review and meta-analysis
title_short Chinese herbal compounds containing scorpion in the treatment of epilepsy: A protocol for systematic review and meta-analysis
title_sort chinese herbal compounds containing scorpion in the treatment of epilepsy: a protocol for systematic review and meta-analysis
topic 3800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969296/
https://www.ncbi.nlm.nih.gov/pubmed/33725915
http://dx.doi.org/10.1097/MD.0000000000025134
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