Deoxyribonuclease 1-Mediated Clearance of Circulating Chromatin Prevents From Immune Cell Activation and Pro-inflammatory Cytokine Production, a Phenomenon Amplified by Low Trap1 Activity: Consequences for Systemic Lupus Erythematosus

Increased concentrations of circulating chromatin, especially oligo-nucleosomes, are observed in sepsis, cancer and some inflammatory autoimmune diseases like systemic lupus erythematosus (SLE). In SLE, circulating nucleosomes mainly result from increased apoptosis and decreased clearance of apoptot...

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Detalles Bibliográficos
Autores principales: Felux, Jasmin, Erbacher, Annika, Breckler, Magali, Hervé, Roxane, Lemeiter, Delphine, Mannherz, Hans Georg, Napirei, Markus, Rammensee, Hans-Georg, Decker, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969502/
https://www.ncbi.nlm.nih.gov/pubmed/33746957
http://dx.doi.org/10.3389/fimmu.2021.613597

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