Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses

Human respiratory syncytial virus (RSV) is a major cause of acute respiratory tract infections in children and immunocompromised adults worldwide. Here we report that amoebae-release respirable-sized vesicles containing high concentrations of infectious RSV that persisted for the duration of the exp...

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Autores principales: Dey, Rafik, Folkins, Melanie A., Ashbolt, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969602/
https://www.ncbi.nlm.nih.gov/pubmed/33731696
http://dx.doi.org/10.1038/s41522-021-00201-y
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author Dey, Rafik
Folkins, Melanie A.
Ashbolt, Nicholas J.
author_facet Dey, Rafik
Folkins, Melanie A.
Ashbolt, Nicholas J.
author_sort Dey, Rafik
collection PubMed
description Human respiratory syncytial virus (RSV) is a major cause of acute respiratory tract infections in children and immunocompromised adults worldwide. Here we report that amoebae-release respirable-sized vesicles containing high concentrations of infectious RSV that persisted for the duration of the experiment. Given the ubiquity of amoebae in moist environments, our results suggest that extracellular amoebal-vesicles could contribute to the environmental persistence of respiratory viruses, including potential resistance to disinfection processes and thereby offering novel pathways for viral dissemination and transmission.
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spelling pubmed-79696022021-04-01 Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses Dey, Rafik Folkins, Melanie A. Ashbolt, Nicholas J. NPJ Biofilms Microbiomes Brief Communication Human respiratory syncytial virus (RSV) is a major cause of acute respiratory tract infections in children and immunocompromised adults worldwide. Here we report that amoebae-release respirable-sized vesicles containing high concentrations of infectious RSV that persisted for the duration of the experiment. Given the ubiquity of amoebae in moist environments, our results suggest that extracellular amoebal-vesicles could contribute to the environmental persistence of respiratory viruses, including potential resistance to disinfection processes and thereby offering novel pathways for viral dissemination and transmission. Nature Publishing Group UK 2021-03-17 /pmc/articles/PMC7969602/ /pubmed/33731696 http://dx.doi.org/10.1038/s41522-021-00201-y Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Dey, Rafik
Folkins, Melanie A.
Ashbolt, Nicholas J.
Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses
title Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses
title_full Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses
title_fullStr Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses
title_full_unstemmed Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses
title_short Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses
title_sort extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969602/
https://www.ncbi.nlm.nih.gov/pubmed/33731696
http://dx.doi.org/10.1038/s41522-021-00201-y
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