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Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

Low differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell cultures, as well as transcriptomic profiling, to investigate how variabili...

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Detalles Bibliográficos
Autores principales:	Dziedzicka, Dominika, Tewary, Mukul, Keller, Alexander, Tilleman, Laurentijn, Prochazka, Laura, Östblom, Joel, Couvreu De Deckersberg, Edouard, Markouli, Christina, Franck, Silvie, Van Nieuwerburgh, Filip, Spits, Claudia, Zandstra, Peter W., Sermon, Karen, Geens, Mieke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969605/ https://www.ncbi.nlm.nih.gov/pubmed/33731744 http://dx.doi.org/10.1038/s41598-021-85447-4

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