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Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients

A simple and accurate prognostic tool for Heart Failure (HF) patients is critical to improve follow-up. Different risk scores are accurate but with limited clinical applicability. The current study aims to derive and validate a simple predictive tool for HF prognosis. French outpatients with stable...

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Detalles Bibliográficos
Autores principales: Duflos, Claire, Solecki, Kamila, Galinier, Michel, Itier, Romain, Roncalli, Jerome, Goger, Anne-Laure, Mandoraah, Bara, Kalmanovich, Eran, Huet, Fabien, Agullo, Audrey, Delseny, Delphine, Macia, Jean-Christophe, Leclercq, Florence, Mercier, Gregoire, Roubille, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969617/
https://www.ncbi.nlm.nih.gov/pubmed/33731823
http://dx.doi.org/10.1038/s41598-021-85767-5
Descripción
Sumario:A simple and accurate prognostic tool for Heart Failure (HF) patients is critical to improve follow-up. Different risk scores are accurate but with limited clinical applicability. The current study aims to derive and validate a simple predictive tool for HF prognosis. French outpatients with stable HF of two university hospitals were included in the derivation (N = 134) or in the validation (N = 274) sample and followed up for a median of 23 months. Potential predictors were variables with known association with mortality and easily available. The proSCANNED risk score was derived using a parametric survival model on complete case data; it includes 8 binary variables and its values are 0–8. In the validation sample, the ability of the score to discriminate the 1-year vital status was moderate (AUC = 0.71, IC95% = [0.64–0.71]). However, the stratification of the score in three groups showed a good calibration for patients in the low- and medium-risk risk group. The proSCANNED score is an easy-to-use tool in clinical practice with a good discrimination, stability, and calibration sufficient to improve the medical care of patients. Other follow up studies are necessary to assess score applicability in larger populations, and its impact.