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Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients

A simple and accurate prognostic tool for Heart Failure (HF) patients is critical to improve follow-up. Different risk scores are accurate but with limited clinical applicability. The current study aims to derive and validate a simple predictive tool for HF prognosis. French outpatients with stable...

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Autores principales: Duflos, Claire, Solecki, Kamila, Galinier, Michel, Itier, Romain, Roncalli, Jerome, Goger, Anne-Laure, Mandoraah, Bara, Kalmanovich, Eran, Huet, Fabien, Agullo, Audrey, Delseny, Delphine, Macia, Jean-Christophe, Leclercq, Florence, Mercier, Gregoire, Roubille, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969617/
https://www.ncbi.nlm.nih.gov/pubmed/33731823
http://dx.doi.org/10.1038/s41598-021-85767-5
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author Duflos, Claire
Solecki, Kamila
Galinier, Michel
Itier, Romain
Roncalli, Jerome
Goger, Anne-Laure
Mandoraah, Bara
Kalmanovich, Eran
Huet, Fabien
Agullo, Audrey
Delseny, Delphine
Macia, Jean-Christophe
Leclercq, Florence
Mercier, Gregoire
Roubille, François
author_facet Duflos, Claire
Solecki, Kamila
Galinier, Michel
Itier, Romain
Roncalli, Jerome
Goger, Anne-Laure
Mandoraah, Bara
Kalmanovich, Eran
Huet, Fabien
Agullo, Audrey
Delseny, Delphine
Macia, Jean-Christophe
Leclercq, Florence
Mercier, Gregoire
Roubille, François
author_sort Duflos, Claire
collection PubMed
description A simple and accurate prognostic tool for Heart Failure (HF) patients is critical to improve follow-up. Different risk scores are accurate but with limited clinical applicability. The current study aims to derive and validate a simple predictive tool for HF prognosis. French outpatients with stable HF of two university hospitals were included in the derivation (N = 134) or in the validation (N = 274) sample and followed up for a median of 23 months. Potential predictors were variables with known association with mortality and easily available. The proSCANNED risk score was derived using a parametric survival model on complete case data; it includes 8 binary variables and its values are 0–8. In the validation sample, the ability of the score to discriminate the 1-year vital status was moderate (AUC = 0.71, IC95% = [0.64–0.71]). However, the stratification of the score in three groups showed a good calibration for patients in the low- and medium-risk risk group. The proSCANNED score is an easy-to-use tool in clinical practice with a good discrimination, stability, and calibration sufficient to improve the medical care of patients. Other follow up studies are necessary to assess score applicability in larger populations, and its impact.
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spelling pubmed-79696172021-03-19 Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients Duflos, Claire Solecki, Kamila Galinier, Michel Itier, Romain Roncalli, Jerome Goger, Anne-Laure Mandoraah, Bara Kalmanovich, Eran Huet, Fabien Agullo, Audrey Delseny, Delphine Macia, Jean-Christophe Leclercq, Florence Mercier, Gregoire Roubille, François Sci Rep Article A simple and accurate prognostic tool for Heart Failure (HF) patients is critical to improve follow-up. Different risk scores are accurate but with limited clinical applicability. The current study aims to derive and validate a simple predictive tool for HF prognosis. French outpatients with stable HF of two university hospitals were included in the derivation (N = 134) or in the validation (N = 274) sample and followed up for a median of 23 months. Potential predictors were variables with known association with mortality and easily available. The proSCANNED risk score was derived using a parametric survival model on complete case data; it includes 8 binary variables and its values are 0–8. In the validation sample, the ability of the score to discriminate the 1-year vital status was moderate (AUC = 0.71, IC95% = [0.64–0.71]). However, the stratification of the score in three groups showed a good calibration for patients in the low- and medium-risk risk group. The proSCANNED score is an easy-to-use tool in clinical practice with a good discrimination, stability, and calibration sufficient to improve the medical care of patients. Other follow up studies are necessary to assess score applicability in larger populations, and its impact. Nature Publishing Group UK 2021-03-17 /pmc/articles/PMC7969617/ /pubmed/33731823 http://dx.doi.org/10.1038/s41598-021-85767-5 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Duflos, Claire
Solecki, Kamila
Galinier, Michel
Itier, Romain
Roncalli, Jerome
Goger, Anne-Laure
Mandoraah, Bara
Kalmanovich, Eran
Huet, Fabien
Agullo, Audrey
Delseny, Delphine
Macia, Jean-Christophe
Leclercq, Florence
Mercier, Gregoire
Roubille, François
Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients
title Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients
title_full Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients
title_fullStr Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients
title_full_unstemmed Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients
title_short Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients
title_sort conception and bicentric validation of the proscanned score, a simplified bedside prognostic score for heart failure patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969617/
https://www.ncbi.nlm.nih.gov/pubmed/33731823
http://dx.doi.org/10.1038/s41598-021-85767-5
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