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The mechanical properties of tibiofemoral and patellofemoral articular cartilage in compression depend on anatomical regions

Articular cartilage in knee joint can be anatomically divided into different regions: medial and lateral condyles of femur; patellar groove of femur; medial and lateral plateaus of tibia covered or uncovered by meniscus. The stress–strain curves of cartilage in uniaxially unconfined compression demo...

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Autores principales: Li, Heng, Li, Jinming, Yu, Shengbo, Wu, Chengwei, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969630/
https://www.ncbi.nlm.nih.gov/pubmed/33731799
http://dx.doi.org/10.1038/s41598-021-85716-2
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author Li, Heng
Li, Jinming
Yu, Shengbo
Wu, Chengwei
Zhang, Wei
author_facet Li, Heng
Li, Jinming
Yu, Shengbo
Wu, Chengwei
Zhang, Wei
author_sort Li, Heng
collection PubMed
description Articular cartilage in knee joint can be anatomically divided into different regions: medial and lateral condyles of femur; patellar groove of femur; medial and lateral plateaus of tibia covered or uncovered by meniscus. The stress–strain curves of cartilage in uniaxially unconfined compression demonstrate strain rate dependency and exhibit distinct topographical variation among these seven regions. The femoral cartilage is stiffer than the tibial cartilage, and the cartilage in femoral groove is stiffest in the knee joint. Compared with the uncovered area, the area covered with meniscus shows the stiffer properties. To investigate the origin of differences in macroscopic mechanical properties, histological analysis of cartilage in seven regions are conducted. The differences are discussed in terms of the cartilage structure, composition content and distribution. Furthermore, the commonly used constitutive models for biological tissues, namely Fung, Ogden and Gent models, are employed to fit the experimental data, and Fung and Ogden models are found to be qualified in representing the stiffening effect of strain rate.
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spelling pubmed-79696302021-03-19 The mechanical properties of tibiofemoral and patellofemoral articular cartilage in compression depend on anatomical regions Li, Heng Li, Jinming Yu, Shengbo Wu, Chengwei Zhang, Wei Sci Rep Article Articular cartilage in knee joint can be anatomically divided into different regions: medial and lateral condyles of femur; patellar groove of femur; medial and lateral plateaus of tibia covered or uncovered by meniscus. The stress–strain curves of cartilage in uniaxially unconfined compression demonstrate strain rate dependency and exhibit distinct topographical variation among these seven regions. The femoral cartilage is stiffer than the tibial cartilage, and the cartilage in femoral groove is stiffest in the knee joint. Compared with the uncovered area, the area covered with meniscus shows the stiffer properties. To investigate the origin of differences in macroscopic mechanical properties, histological analysis of cartilage in seven regions are conducted. The differences are discussed in terms of the cartilage structure, composition content and distribution. Furthermore, the commonly used constitutive models for biological tissues, namely Fung, Ogden and Gent models, are employed to fit the experimental data, and Fung and Ogden models are found to be qualified in representing the stiffening effect of strain rate. Nature Publishing Group UK 2021-03-17 /pmc/articles/PMC7969630/ /pubmed/33731799 http://dx.doi.org/10.1038/s41598-021-85716-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Heng
Li, Jinming
Yu, Shengbo
Wu, Chengwei
Zhang, Wei
The mechanical properties of tibiofemoral and patellofemoral articular cartilage in compression depend on anatomical regions
title The mechanical properties of tibiofemoral and patellofemoral articular cartilage in compression depend on anatomical regions
title_full The mechanical properties of tibiofemoral and patellofemoral articular cartilage in compression depend on anatomical regions
title_fullStr The mechanical properties of tibiofemoral and patellofemoral articular cartilage in compression depend on anatomical regions
title_full_unstemmed The mechanical properties of tibiofemoral and patellofemoral articular cartilage in compression depend on anatomical regions
title_short The mechanical properties of tibiofemoral and patellofemoral articular cartilage in compression depend on anatomical regions
title_sort mechanical properties of tibiofemoral and patellofemoral articular cartilage in compression depend on anatomical regions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969630/
https://www.ncbi.nlm.nih.gov/pubmed/33731799
http://dx.doi.org/10.1038/s41598-021-85716-2
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