Critical Role of TLR4 on the Microglia Activation Induced by Maternal LPS Exposure Leading to ASD-Like Behavior of Offspring

Objective: To investigate the role of TLR4 on the microglia activation in the pre-frontal cortex, which leads to autism-like behavior of the offspring induced by maternal lipopolysaccharide (LPS) exposure. Methods: Pregnant TLR4(−/−) (knockout, KO) and WT (wild type, WT) dams were intraperitoneally...

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Detalles Bibliográficos
Autores principales: Xiao, Lu, Yan, Junyan, Feng, Di, Ye, Shasha, Yang, Ting, Wei, Hua, Li, Tingyu, Sun, Wuqing, Chen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969707/
https://www.ncbi.nlm.nih.gov/pubmed/33748121
http://dx.doi.org/10.3389/fcell.2021.634837

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