The emerging role of ferroptosis in intestinal disease

Ferroptosis is a newly recognised type of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid peroxidation. It is significantly distinct from other RCDs at the morphological, biochemical, and genetic levels. Recent reports have implicated ferroptosis in multiple diseases...

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Autores principales: Xu, Shu, He, Yao, Lin, Lihui, Chen, Peng, Chen, Minhu, Zhang, Shenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969743/
https://www.ncbi.nlm.nih.gov/pubmed/33731703
http://dx.doi.org/10.1038/s41419-021-03559-1
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author Xu, Shu
He, Yao
Lin, Lihui
Chen, Peng
Chen, Minhu
Zhang, Shenghong
author_facet Xu, Shu
He, Yao
Lin, Lihui
Chen, Peng
Chen, Minhu
Zhang, Shenghong
author_sort Xu, Shu
collection PubMed
description Ferroptosis is a newly recognised type of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid peroxidation. It is significantly distinct from other RCDs at the morphological, biochemical, and genetic levels. Recent reports have implicated ferroptosis in multiple diseases, including neurological disorders, kidney injury, liver diseases, and cancer. Ferroptotic cell death has also been associated with dysfunction of the intestinal epithelium, which contributes to several intestinal diseases. Research on ferroptosis may provide a new understanding of intestinal disease pathogenesis that benefits clinical treatment. In this review, we provide an overview of ferroptosis and its underlying mechanisms, then describe its emerging role in intestinal diseases, including intestinal ischaemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), and colorectal cancer (CRC).
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spelling pubmed-79697432021-04-12 The emerging role of ferroptosis in intestinal disease Xu, Shu He, Yao Lin, Lihui Chen, Peng Chen, Minhu Zhang, Shenghong Cell Death Dis Review Article Ferroptosis is a newly recognised type of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid peroxidation. It is significantly distinct from other RCDs at the morphological, biochemical, and genetic levels. Recent reports have implicated ferroptosis in multiple diseases, including neurological disorders, kidney injury, liver diseases, and cancer. Ferroptotic cell death has also been associated with dysfunction of the intestinal epithelium, which contributes to several intestinal diseases. Research on ferroptosis may provide a new understanding of intestinal disease pathogenesis that benefits clinical treatment. In this review, we provide an overview of ferroptosis and its underlying mechanisms, then describe its emerging role in intestinal diseases, including intestinal ischaemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), and colorectal cancer (CRC). Nature Publishing Group UK 2021-03-17 /pmc/articles/PMC7969743/ /pubmed/33731703 http://dx.doi.org/10.1038/s41419-021-03559-1 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Xu, Shu
He, Yao
Lin, Lihui
Chen, Peng
Chen, Minhu
Zhang, Shenghong
The emerging role of ferroptosis in intestinal disease
title The emerging role of ferroptosis in intestinal disease
title_full The emerging role of ferroptosis in intestinal disease
title_fullStr The emerging role of ferroptosis in intestinal disease
title_full_unstemmed The emerging role of ferroptosis in intestinal disease
title_short The emerging role of ferroptosis in intestinal disease
title_sort emerging role of ferroptosis in intestinal disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969743/
https://www.ncbi.nlm.nih.gov/pubmed/33731703
http://dx.doi.org/10.1038/s41419-021-03559-1
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