Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are very limited and the underlying mechanisms are poorly understood. We report that bone-borne TGF-β induces the acetylation of transcription factor KLF5 in PCa bone metastases, and acetylated KLF5 (Ac-KLF5) causes o...

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Detalles Bibliográficos
Autores principales: Zhang, Baotong, Li, Yixiang, Wu, Qiao, Xie, Lin, Barwick, Benjamin, Fu, Changying, Li, Xin, Wu, Daqing, Xia, Siyuan, Chen, Jing, Qian, Wei Ping, Yang, Lily, Osunkoya, Adeboye O., Boise, Lawrence, Vertino, Paula M., Zhao, Yichao, Li, Menglin, Chen, Hsiao-Rong, Kowalski, Jeanne, Kucuk, Omer, Zhou, Wei, Dong, Jin-Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969754/
https://www.ncbi.nlm.nih.gov/pubmed/33731701
http://dx.doi.org/10.1038/s41467-021-21976-w

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