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A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies
The coronavirus spike glycoprotein, located on the virion surface, is the key mediator of cell entry and the focus for development of protective antibodies and vaccines. Structural studies show exposed sites on the spike trimer that might be targeted by antibodies with cross-species specificity. Her...
Autores principales: | Wang, Chunyan, van Haperen, Rien, Gutiérrez-Álvarez, Javier, Li, Wentao, Okba, Nisreen M. A., Albulescu, Irina, Widjaja, Ivy, van Dieren, Brenda, Fernandez-Delgado, Raul, Sola, Isabel, Hurdiss, Daniel L., Daramola, Olalekan, Grosveld, Frank, van Kuppeveld, Frank J. M., Haagmans, Bart L., Enjuanes, Luis, Drabek, Dubravka, Bosch, Berend-Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969777/ https://www.ncbi.nlm.nih.gov/pubmed/33731724 http://dx.doi.org/10.1038/s41467-021-21968-w |
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