Cargando…

Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes

There is mounting evidence linking the cumulative effects of repetitive head impacts to neuro-degenerative conditions. Robust clinical assessment tools to identify mild traumatic brain injuries are needed to assist with timely diagnosis for return-to-field decisions and appropriately guide rehabilit...

Descripción completa

Detalles Bibliográficos
Autores principales: Rao, Hrishikesh M., Yuditskaya, Sophia, Williamson, James R., Vian, Trina R., Lacirignola, Joseph J., Shenk, Trey E., Talavage, Thomas M., Heaton, Kristin J., Quatieri, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969804/
https://www.ncbi.nlm.nih.gov/pubmed/33746869
http://dx.doi.org/10.3389/fneur.2021.584684
_version_ 1783666302256152576
author Rao, Hrishikesh M.
Yuditskaya, Sophia
Williamson, James R.
Vian, Trina R.
Lacirignola, Joseph J.
Shenk, Trey E.
Talavage, Thomas M.
Heaton, Kristin J.
Quatieri, Thomas F.
author_facet Rao, Hrishikesh M.
Yuditskaya, Sophia
Williamson, James R.
Vian, Trina R.
Lacirignola, Joseph J.
Shenk, Trey E.
Talavage, Thomas M.
Heaton, Kristin J.
Quatieri, Thomas F.
author_sort Rao, Hrishikesh M.
collection PubMed
description There is mounting evidence linking the cumulative effects of repetitive head impacts to neuro-degenerative conditions. Robust clinical assessment tools to identify mild traumatic brain injuries are needed to assist with timely diagnosis for return-to-field decisions and appropriately guide rehabilitation. The focus of the present study is to investigate the potential for oculomotor features to complement existing diagnostic tools, such as measurements of Optic Nerve Sheath Diameter (ONSD) and Immediate Post-concussion Assessment and Cognitive Testing (ImPACT). Thirty-one high school American football and soccer athletes were tracked through the course of a sports season. Given the high risk of repetitive head impacts associated with both soccer and football, our hypotheses were that (1) ONSD and ImPACT scores would worsen through the season and (2) oculomotor features would effectively capture both neurophysiological changes reflected by ONSD and neuro-functional status assessed via ImPACT. Oculomotor features were used as input to Linear Mixed-Effects Regression models to predict ONSD and ImPACT scores as outcomes. Prediction accuracy was evaluated to identify explicit relationships between eye movements, ONSD, and ImPACT scores. Significant Pearson correlations were observed between predicted and actual outcomes for ONSD (Raw = 0.70; Normalized = 0.45) and for ImPACT (Raw = 0.86; Normalized = 0.71), demonstrating the capability of oculomotor features to capture neurological changes detected by both ONSD and ImPACT. The most predictive features were found to relate to motor control and visual-motor processing. In future work, oculomotor models, linking neural structures to oculomotor function, can be built to gain extended mechanistic insights into neurophysiological changes observed through seasons of participation in contact sports.
format Online
Article
Text
id pubmed-7969804
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79698042021-03-19 Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes Rao, Hrishikesh M. Yuditskaya, Sophia Williamson, James R. Vian, Trina R. Lacirignola, Joseph J. Shenk, Trey E. Talavage, Thomas M. Heaton, Kristin J. Quatieri, Thomas F. Front Neurol Neurology There is mounting evidence linking the cumulative effects of repetitive head impacts to neuro-degenerative conditions. Robust clinical assessment tools to identify mild traumatic brain injuries are needed to assist with timely diagnosis for return-to-field decisions and appropriately guide rehabilitation. The focus of the present study is to investigate the potential for oculomotor features to complement existing diagnostic tools, such as measurements of Optic Nerve Sheath Diameter (ONSD) and Immediate Post-concussion Assessment and Cognitive Testing (ImPACT). Thirty-one high school American football and soccer athletes were tracked through the course of a sports season. Given the high risk of repetitive head impacts associated with both soccer and football, our hypotheses were that (1) ONSD and ImPACT scores would worsen through the season and (2) oculomotor features would effectively capture both neurophysiological changes reflected by ONSD and neuro-functional status assessed via ImPACT. Oculomotor features were used as input to Linear Mixed-Effects Regression models to predict ONSD and ImPACT scores as outcomes. Prediction accuracy was evaluated to identify explicit relationships between eye movements, ONSD, and ImPACT scores. Significant Pearson correlations were observed between predicted and actual outcomes for ONSD (Raw = 0.70; Normalized = 0.45) and for ImPACT (Raw = 0.86; Normalized = 0.71), demonstrating the capability of oculomotor features to capture neurological changes detected by both ONSD and ImPACT. The most predictive features were found to relate to motor control and visual-motor processing. In future work, oculomotor models, linking neural structures to oculomotor function, can be built to gain extended mechanistic insights into neurophysiological changes observed through seasons of participation in contact sports. Frontiers Media S.A. 2021-03-04 /pmc/articles/PMC7969804/ /pubmed/33746869 http://dx.doi.org/10.3389/fneur.2021.584684 Text en Copyright © 2021 Rao, Yuditskaya, Williamson, Vian, Lacirignola, Shenk, Talavage, Heaton and Quatieri. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Rao, Hrishikesh M.
Yuditskaya, Sophia
Williamson, James R.
Vian, Trina R.
Lacirignola, Joseph J.
Shenk, Trey E.
Talavage, Thomas M.
Heaton, Kristin J.
Quatieri, Thomas F.
Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes
title Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes
title_full Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes
title_fullStr Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes
title_full_unstemmed Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes
title_short Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes
title_sort using oculomotor features to predict changes in optic nerve sheath diameter and impact scores from contact-sport athletes
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969804/
https://www.ncbi.nlm.nih.gov/pubmed/33746869
http://dx.doi.org/10.3389/fneur.2021.584684
work_keys_str_mv AT raohrishikeshm usingoculomotorfeaturestopredictchangesinopticnervesheathdiameterandimpactscoresfromcontactsportathletes
AT yuditskayasophia usingoculomotorfeaturestopredictchangesinopticnervesheathdiameterandimpactscoresfromcontactsportathletes
AT williamsonjamesr usingoculomotorfeaturestopredictchangesinopticnervesheathdiameterandimpactscoresfromcontactsportathletes
AT viantrinar usingoculomotorfeaturestopredictchangesinopticnervesheathdiameterandimpactscoresfromcontactsportathletes
AT lacirignolajosephj usingoculomotorfeaturestopredictchangesinopticnervesheathdiameterandimpactscoresfromcontactsportathletes
AT shenktreye usingoculomotorfeaturestopredictchangesinopticnervesheathdiameterandimpactscoresfromcontactsportathletes
AT talavagethomasm usingoculomotorfeaturestopredictchangesinopticnervesheathdiameterandimpactscoresfromcontactsportathletes
AT heatonkristinj usingoculomotorfeaturestopredictchangesinopticnervesheathdiameterandimpactscoresfromcontactsportathletes
AT quatierithomasf usingoculomotorfeaturestopredictchangesinopticnervesheathdiameterandimpactscoresfromcontactsportathletes