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Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ

Aging-associated chronic inflammation is a key contributing factor to a cluster of chronic metabolic disorders, such as cardiovascular disease, obesity, and type 2 diabetes. Immune cells particularly T cells accumulate in adipose tissue with advancing age, and there exists a cross talk between T cel...

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Autores principales: Pan, Xiao-Xi, Yao, Kang-Li, Yang, Yong-Feng, Ge, Qian, Zhang, Run, Gao, Ping-Jin, Ruan, Cheng-Chao, Wu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969812/
https://www.ncbi.nlm.nih.gov/pubmed/33748126
http://dx.doi.org/10.3389/fcell.2021.637424
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author Pan, Xiao-Xi
Yao, Kang-Li
Yang, Yong-Feng
Ge, Qian
Zhang, Run
Gao, Ping-Jin
Ruan, Cheng-Chao
Wu, Fang
author_facet Pan, Xiao-Xi
Yao, Kang-Li
Yang, Yong-Feng
Ge, Qian
Zhang, Run
Gao, Ping-Jin
Ruan, Cheng-Chao
Wu, Fang
author_sort Pan, Xiao-Xi
collection PubMed
description Aging-associated chronic inflammation is a key contributing factor to a cluster of chronic metabolic disorders, such as cardiovascular disease, obesity, and type 2 diabetes. Immune cells particularly T cells accumulate in adipose tissue with advancing age, and there exists a cross talk between T cell and preadipocyte, contributing to age-related adipose tissue remodeling. Here, we compared the difference in morphology and function of adipose tissue between young (3-month-old) and old (18-month-old) mice and showed the phenomenon of brown adipose tissue (BAT) “whitening” in old mice. Flow cytometry analysis suggested an increased proportion of T cells in BAT of old mice comparing with the young and exhibited senescent characteristics. We take advantage of coculture system to demonstrate directly that senescent T cells inhibited brown adipocyte differentiation of preadipocytes in adipose tissue. Mechanistically, both in vitro and in vivo studies suggested that senescent T cells produced and released a higher level of IFN-γ, which plays a critical role in inhibition of preadipocyte-to-brown adipocyte differentiation. Taken together, the data indicate that senescent T cell-derived IFN-γ is a key regulator in brown adipocyte differentiation.
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spelling pubmed-79698122021-03-19 Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ Pan, Xiao-Xi Yao, Kang-Li Yang, Yong-Feng Ge, Qian Zhang, Run Gao, Ping-Jin Ruan, Cheng-Chao Wu, Fang Front Cell Dev Biol Cell and Developmental Biology Aging-associated chronic inflammation is a key contributing factor to a cluster of chronic metabolic disorders, such as cardiovascular disease, obesity, and type 2 diabetes. Immune cells particularly T cells accumulate in adipose tissue with advancing age, and there exists a cross talk between T cell and preadipocyte, contributing to age-related adipose tissue remodeling. Here, we compared the difference in morphology and function of adipose tissue between young (3-month-old) and old (18-month-old) mice and showed the phenomenon of brown adipose tissue (BAT) “whitening” in old mice. Flow cytometry analysis suggested an increased proportion of T cells in BAT of old mice comparing with the young and exhibited senescent characteristics. We take advantage of coculture system to demonstrate directly that senescent T cells inhibited brown adipocyte differentiation of preadipocytes in adipose tissue. Mechanistically, both in vitro and in vivo studies suggested that senescent T cells produced and released a higher level of IFN-γ, which plays a critical role in inhibition of preadipocyte-to-brown adipocyte differentiation. Taken together, the data indicate that senescent T cell-derived IFN-γ is a key regulator in brown adipocyte differentiation. Frontiers Media S.A. 2021-03-04 /pmc/articles/PMC7969812/ /pubmed/33748126 http://dx.doi.org/10.3389/fcell.2021.637424 Text en Copyright © 2021 Pan, Yao, Yang, Ge, Zhang, Gao, Ruan and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Pan, Xiao-Xi
Yao, Kang-Li
Yang, Yong-Feng
Ge, Qian
Zhang, Run
Gao, Ping-Jin
Ruan, Cheng-Chao
Wu, Fang
Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ
title Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ
title_full Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ
title_fullStr Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ
title_full_unstemmed Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ
title_short Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ
title_sort senescent t cell induces brown adipose tissue “whitening” via secreting ifn-γ
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969812/
https://www.ncbi.nlm.nih.gov/pubmed/33748126
http://dx.doi.org/10.3389/fcell.2021.637424
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