Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication

SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. We developed a medium-throughput drug-screening system and identified a small-molecule library of 34 of 430 protein kinase inhibitors that were capable of inhibiting the SARS-CoV-2 cytopathic effect in human epithelial cells. T...

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Detalles Bibliográficos
Autores principales: Garcia, Gustavo, Sharma, Arun, Ramaiah, Arunachalam, Sen, Chandani, Purkayastha, Arunima, Kohn, Donald B., Parcells, Mark S., Beck, Sebastian, Kim, Heeyoung, Bakowski, Malina A., Kirkpatrick, Melanie G., Riva, Laura, Wolff, Karen C., Han, Brandon, Yuen, Constance, Ulmert, David, Purbey, Prabhat K., Scumpia, Phillip, Beutler, Nathan, Rogers, Thomas F., Chatterjee, Arnab K., Gabriel, Gülsah, Bartenschlager, Ralf, Gomperts, Brigitte, Svendsen, Clive N., Betz, Ulrich A.K., Damoiseaux, Robert D., Arumugaswami, Vaithilingaraja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969873/
https://www.ncbi.nlm.nih.gov/pubmed/33784499
http://dx.doi.org/10.1016/j.celrep.2021.108940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969873/
https://www.ncbi.nlm.nih.gov/pubmed/33784499
http://dx.doi.org/10.1016/j.celrep.2021.108940

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