Cargando…

Recent Topics and Perspectives on Esophageal Cancer in Japan

Despite recent advances in multidisciplinary treatment strategy, outcomes of esophageal cancer treatment still remain unsatisfactory. There are two histologic subtypes of esophageal cancer, namely, squamous cell carcinoma and adenocarcinoma, and these subtypes turned out to be genetically separate d...

Descripción completa

Detalles Bibliográficos
Autor principal: Watanabe, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Medical Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969908/
https://www.ncbi.nlm.nih.gov/pubmed/33748520
http://dx.doi.org/10.31662/jmaj.2018-0002
_version_ 1783666326281125888
author Watanabe, Masayuki
author_facet Watanabe, Masayuki
author_sort Watanabe, Masayuki
collection PubMed
description Despite recent advances in multidisciplinary treatment strategy, outcomes of esophageal cancer treatment still remain unsatisfactory. There are two histologic subtypes of esophageal cancer, namely, squamous cell carcinoma and adenocarcinoma, and these subtypes turned out to be genetically separate diseases. I focused on nine topics among the cancer's epidemiology, diagnosis, and treatment, and reviewed the literature. Although the number of patients with esophageal cancer has been continuously increasing, the cause of esophageal cancer is evident in a substantial proportion of patients, and public education may be able to decrease its incidence. Early detection and less invasive treatment will improve the outcome of patients. Minimally invasive esophagectomy decreased surgical invasiveness and improved short-term outcomes in the clinical trials. Centralization of patients to high-volume centers and introduction of multidisciplinary perioperative care bundle may further improve the outcome of patients undergoing esophagectomy. Although no targeting agent has shown efficacy in patients with esophageal cancer, immune checkpoint blockades are promising, and the results of phase III trials are awaited.
format Online
Article
Text
id pubmed-7969908
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Japan Medical Association
record_format MEDLINE/PubMed
spelling pubmed-79699082021-03-18 Recent Topics and Perspectives on Esophageal Cancer in Japan Watanabe, Masayuki JMA J Review Article Despite recent advances in multidisciplinary treatment strategy, outcomes of esophageal cancer treatment still remain unsatisfactory. There are two histologic subtypes of esophageal cancer, namely, squamous cell carcinoma and adenocarcinoma, and these subtypes turned out to be genetically separate diseases. I focused on nine topics among the cancer's epidemiology, diagnosis, and treatment, and reviewed the literature. Although the number of patients with esophageal cancer has been continuously increasing, the cause of esophageal cancer is evident in a substantial proportion of patients, and public education may be able to decrease its incidence. Early detection and less invasive treatment will improve the outcome of patients. Minimally invasive esophagectomy decreased surgical invasiveness and improved short-term outcomes in the clinical trials. Centralization of patients to high-volume centers and introduction of multidisciplinary perioperative care bundle may further improve the outcome of patients undergoing esophagectomy. Although no targeting agent has shown efficacy in patients with esophageal cancer, immune checkpoint blockades are promising, and the results of phase III trials are awaited. Japan Medical Association 2018-09-28 2018-09-28 /pmc/articles/PMC7969908/ /pubmed/33748520 http://dx.doi.org/10.31662/jmaj.2018-0002 Text en Copyright © Japan Medical Association http://creativecommons.org/licenses/by/4.0/ JMA Journal is an Open Access journal distributed under the Creative Commons Attribution 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Watanabe, Masayuki
Recent Topics and Perspectives on Esophageal Cancer in Japan
title Recent Topics and Perspectives on Esophageal Cancer in Japan
title_full Recent Topics and Perspectives on Esophageal Cancer in Japan
title_fullStr Recent Topics and Perspectives on Esophageal Cancer in Japan
title_full_unstemmed Recent Topics and Perspectives on Esophageal Cancer in Japan
title_short Recent Topics and Perspectives on Esophageal Cancer in Japan
title_sort recent topics and perspectives on esophageal cancer in japan
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969908/
https://www.ncbi.nlm.nih.gov/pubmed/33748520
http://dx.doi.org/10.31662/jmaj.2018-0002
work_keys_str_mv AT watanabemasayuki recenttopicsandperspectivesonesophagealcancerinjapan