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Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration

Anomalous patterns of brain gyrification have been reported in major psychiatric disorders, presumably reflecting their neurodevelopmental pathology. However, previous reports presented conflicting results of patients having hyper-, hypo-, or normal gyrification patterns and lacking in transdiagnost...

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Autores principales: Sasabayashi, Daiki, Takahashi, Tsutomu, Takayanagi, Yoichiro, Suzuki, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969935/
https://www.ncbi.nlm.nih.gov/pubmed/33731700
http://dx.doi.org/10.1038/s41398-021-01297-8
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author Sasabayashi, Daiki
Takahashi, Tsutomu
Takayanagi, Yoichiro
Suzuki, Michio
author_facet Sasabayashi, Daiki
Takahashi, Tsutomu
Takayanagi, Yoichiro
Suzuki, Michio
author_sort Sasabayashi, Daiki
collection PubMed
description Anomalous patterns of brain gyrification have been reported in major psychiatric disorders, presumably reflecting their neurodevelopmental pathology. However, previous reports presented conflicting results of patients having hyper-, hypo-, or normal gyrification patterns and lacking in transdiagnostic consideration. In this article, we systematically review previous magnetic resonance imaging studies of brain gyrification in schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder at varying illness stages, highlighting the gyral pattern trajectory for each disorder. Patients with each psychiatric disorder may exhibit deviated primary gyri formation under neurodevelopmental genetic control in their fetal life and infancy, and then exhibit higher-order gyral changes due to mechanical stress from active brain changes (e.g., progressive reduction of gray matter volume and white matter integrity) thereafter, representing diversely altered pattern trajectories from those of healthy controls. Based on the patterns of local connectivity and changes in neurodevelopmental gene expression in major psychiatric disorders, we propose an overarching model that spans the diagnoses to explain how deviated gyral pattern trajectories map onto clinical manifestations (e.g., psychosis, mood dysregulation, and cognitive impairments), focusing on the common and distinct gyral pattern changes across the disorders in addition to their correlations with specific clinical features. This comprehensive understanding of the role of brain gyrification pattern on the pathophysiology may help to optimize the prediction and diagnosis of psychiatric disorders using objective biomarkers, as well as provide a novel nosology informed by neural circuits beyond the current descriptive diagnostics.
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spelling pubmed-79699352021-04-12 Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration Sasabayashi, Daiki Takahashi, Tsutomu Takayanagi, Yoichiro Suzuki, Michio Transl Psychiatry Review Article Anomalous patterns of brain gyrification have been reported in major psychiatric disorders, presumably reflecting their neurodevelopmental pathology. However, previous reports presented conflicting results of patients having hyper-, hypo-, or normal gyrification patterns and lacking in transdiagnostic consideration. In this article, we systematically review previous magnetic resonance imaging studies of brain gyrification in schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder at varying illness stages, highlighting the gyral pattern trajectory for each disorder. Patients with each psychiatric disorder may exhibit deviated primary gyri formation under neurodevelopmental genetic control in their fetal life and infancy, and then exhibit higher-order gyral changes due to mechanical stress from active brain changes (e.g., progressive reduction of gray matter volume and white matter integrity) thereafter, representing diversely altered pattern trajectories from those of healthy controls. Based on the patterns of local connectivity and changes in neurodevelopmental gene expression in major psychiatric disorders, we propose an overarching model that spans the diagnoses to explain how deviated gyral pattern trajectories map onto clinical manifestations (e.g., psychosis, mood dysregulation, and cognitive impairments), focusing on the common and distinct gyral pattern changes across the disorders in addition to their correlations with specific clinical features. This comprehensive understanding of the role of brain gyrification pattern on the pathophysiology may help to optimize the prediction and diagnosis of psychiatric disorders using objective biomarkers, as well as provide a novel nosology informed by neural circuits beyond the current descriptive diagnostics. Nature Publishing Group UK 2021-03-17 /pmc/articles/PMC7969935/ /pubmed/33731700 http://dx.doi.org/10.1038/s41398-021-01297-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Sasabayashi, Daiki
Takahashi, Tsutomu
Takayanagi, Yoichiro
Suzuki, Michio
Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration
title Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration
title_full Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration
title_fullStr Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration
title_full_unstemmed Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration
title_short Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration
title_sort anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969935/
https://www.ncbi.nlm.nih.gov/pubmed/33731700
http://dx.doi.org/10.1038/s41398-021-01297-8
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