Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition

Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of NSSM are...

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Autores principales: Masood, Ashiq, Christ, Trevor, Asif, Samia, Rajakumar, Priya, Gustafson, Beth A., Shune, Leyla O., Salahudeen, Ameen, Nedvad, Drew, Nanua, Suparna, Paner, Agne, Kuzel, Timothy M., Levy, Mia, Subramanian, Janakiraman, Raza, Shahzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969947/
https://www.ncbi.nlm.nih.gov/pubmed/33731690
http://dx.doi.org/10.1038/s41525-021-00186-9
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author Masood, Ashiq
Christ, Trevor
Asif, Samia
Rajakumar, Priya
Gustafson, Beth A.
Shune, Leyla O.
Salahudeen, Ameen
Nedvad, Drew
Nanua, Suparna
Paner, Agne
Kuzel, Timothy M.
Levy, Mia
Subramanian, Janakiraman
Raza, Shahzad
author_facet Masood, Ashiq
Christ, Trevor
Asif, Samia
Rajakumar, Priya
Gustafson, Beth A.
Shune, Leyla O.
Salahudeen, Ameen
Nedvad, Drew
Nanua, Suparna
Paner, Agne
Kuzel, Timothy M.
Levy, Mia
Subramanian, Janakiraman
Raza, Shahzad
author_sort Masood, Ashiq
collection PubMed
description Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of NSSM are not well characterized. Here, we report a case of a patient with relapsed and refractory NSMM with brain metastasis harboring a TFG-ALK fusion showing a dramatic and durable (over two years) response to commercially available anaplastic lymphoma kinase (ALK) inhibitors. The case emphasizes the beneficial role of molecular profiling in this target-poor disease.
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spelling pubmed-79699472021-04-12 Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition Masood, Ashiq Christ, Trevor Asif, Samia Rajakumar, Priya Gustafson, Beth A. Shune, Leyla O. Salahudeen, Ameen Nedvad, Drew Nanua, Suparna Paner, Agne Kuzel, Timothy M. Levy, Mia Subramanian, Janakiraman Raza, Shahzad NPJ Genom Med Case Report Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of NSSM are not well characterized. Here, we report a case of a patient with relapsed and refractory NSMM with brain metastasis harboring a TFG-ALK fusion showing a dramatic and durable (over two years) response to commercially available anaplastic lymphoma kinase (ALK) inhibitors. The case emphasizes the beneficial role of molecular profiling in this target-poor disease. Nature Publishing Group UK 2021-03-17 /pmc/articles/PMC7969947/ /pubmed/33731690 http://dx.doi.org/10.1038/s41525-021-00186-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Masood, Ashiq
Christ, Trevor
Asif, Samia
Rajakumar, Priya
Gustafson, Beth A.
Shune, Leyla O.
Salahudeen, Ameen
Nedvad, Drew
Nanua, Suparna
Paner, Agne
Kuzel, Timothy M.
Levy, Mia
Subramanian, Janakiraman
Raza, Shahzad
Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title_full Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title_fullStr Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title_full_unstemmed Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title_short Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title_sort non-secretory multiple myeloma with unusual tfg-alk fusion showed dramatic response to alk inhibition
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969947/
https://www.ncbi.nlm.nih.gov/pubmed/33731690
http://dx.doi.org/10.1038/s41525-021-00186-9
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