Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney

Inhibition of the eukaryotic initiation factor 5A activation by the spermidine analogue GC7 has been shown to protect proximal cells and whole kidneys against an acute episode of ischaemia. The highlighted mechanism involves a metabolic switch from oxidative phosphorylation toward glycolysis allowin...

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Detalles Bibliográficos
Autores principales: Cougnon, Marc, Carcy, Romain, Melis, Nicolas, Rubera, Isabelle, Duranton, Christophe, Dumas, Karine, Tanti, Jean-François, Pons, Catherine, Soubeiran, Nicolas, Shkreli, Marina, Hauet, Thierry, Pellerin, Luc, Giraud, Sébastien, Blondeau, Nicolas, Tauc, Michel, Pisani, Didier F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969969/
https://www.ncbi.nlm.nih.gov/pubmed/33731685
http://dx.doi.org/10.1038/s41419-021-03577-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969969/
https://www.ncbi.nlm.nih.gov/pubmed/33731685
http://dx.doi.org/10.1038/s41419-021-03577-z

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