Small Molecule Cjoc42 Improves Chemo-Sensitivity and Increases Levels of Tumor Suppressor Proteins in Hepatoblastoma Cells and in Mice by Inhibiting Oncogene Gankyrin

Objective: Relapsed hepatoblastoma (HBL) and upfront hepatocellular carcinoma (HCC) are notoriously chemoresistant tumors associated with poor outcomes. Gankyrin (Gank) is a known oncogene that is overexpressed in pediatric liver cancer and implicated in chemo-resistance. The goal of this study was...

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Detalles Bibliográficos
Autores principales: D’Souza, Amber M., Cast, Ashley, Kumbaji, Meenasri, Rivas, Maria, Gulati, Ruhi, Johnston, Michael, Smithrud, David, Geller, James, Timchenko, Nikolai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969996/
https://www.ncbi.nlm.nih.gov/pubmed/33746747
http://dx.doi.org/10.3389/fphar.2021.580722

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