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Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence
BACKGROUND: In multiple sclerosis loss of myelin and oligodendrocytes impairs saltatory signal transduction and leads to neuronal loss and functional deficits. Limited capacity of oligodendroglial precursor cells to differentiate into mature cells is the main reason for inefficient myelin repair in...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970057/ https://www.ncbi.nlm.nih.gov/pubmed/33714029 http://dx.doi.org/10.1016/j.ebiom.2021.103276 |