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The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma
BACKGROUND: In this study, we aimed to investigate the prognostic value of metabolic (18)F-fluorodeoxyglucose positron emission tomography/computed tomography parameters in malignant pleural mesothelioma patients. METHODS: A total of 65 patients with malignant pleural mesothelioma (34 males, 31 fema...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bayçınar Medical Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970077/ https://www.ncbi.nlm.nih.gov/pubmed/33768986 http://dx.doi.org/10.5606/tgkdc.dergisi.2021.20432 |
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author | Yenigün, Bülent Mustafa Kahya, Yusuf Soydal, Çiğdem Ata Tutkun, Nihal Kocaman, Gökhan Koçak, Emre Muhammed Özkan, Elgin Dizbay Sak, Serpil Kayı Cangır, Ayten |
author_facet | Yenigün, Bülent Mustafa Kahya, Yusuf Soydal, Çiğdem Ata Tutkun, Nihal Kocaman, Gökhan Koçak, Emre Muhammed Özkan, Elgin Dizbay Sak, Serpil Kayı Cangır, Ayten |
author_sort | Yenigün, Bülent Mustafa |
collection | PubMed |
description | BACKGROUND: In this study, we aimed to investigate the prognostic value of metabolic (18)F-fluorodeoxyglucose positron emission tomography/computed tomography parameters in malignant pleural mesothelioma patients. METHODS: A total of 65 patients with malignant pleural mesothelioma (34 males, 31 females; median age: 60 years; range, 39 to 84 years) who underwent whole-body (18)F-fluorodeoxyglucose positron emission tomography/computed tomography for staging before treatment between March 2008 and January 2018 were included. Relationships between clinicopathological factors and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography parameters and overall survival were evaluated using a log-rank test and Cox regression analysis. RESULTS: The median follow-up was 13 (range, 4 to 55) months. The Kaplan-Meier analysis revealed a mean survival time of 17±2.6 months. The cumulative two- and five-year survival rates were 34.8% and 7.8%, respectively. Univariate analysis showed that ≥60 age, left hemithorax involvement, a maximum standardized uptake value of ≥9.8, c-T4 status, c-M1 status, and non-surgery were negatively associated with overall survival (p<0.05). Multivariate analysis showed that ≥60 age, left hemithorax involvement, a maximum standardized uptake value of ≥9.8, c-M1 status, and a total lesion glycolysis of ≥180.2 g were negatively associated with overall survival (p<0.05). CONCLUSION: Metabolic parameters of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography have the potential to provide prognostic information for malignant pleural mesothelioma patients who are receiving surgery and/or chemotherapy. |
format | Online Article Text |
id | pubmed-7970077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Bayçınar Medical Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-79700772021-03-24 The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma Yenigün, Bülent Mustafa Kahya, Yusuf Soydal, Çiğdem Ata Tutkun, Nihal Kocaman, Gökhan Koçak, Emre Muhammed Özkan, Elgin Dizbay Sak, Serpil Kayı Cangır, Ayten Turk Gogus Kalp Damar Cerrahisi Derg Original Article BACKGROUND: In this study, we aimed to investigate the prognostic value of metabolic (18)F-fluorodeoxyglucose positron emission tomography/computed tomography parameters in malignant pleural mesothelioma patients. METHODS: A total of 65 patients with malignant pleural mesothelioma (34 males, 31 females; median age: 60 years; range, 39 to 84 years) who underwent whole-body (18)F-fluorodeoxyglucose positron emission tomography/computed tomography for staging before treatment between March 2008 and January 2018 were included. Relationships between clinicopathological factors and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography parameters and overall survival were evaluated using a log-rank test and Cox regression analysis. RESULTS: The median follow-up was 13 (range, 4 to 55) months. The Kaplan-Meier analysis revealed a mean survival time of 17±2.6 months. The cumulative two- and five-year survival rates were 34.8% and 7.8%, respectively. Univariate analysis showed that ≥60 age, left hemithorax involvement, a maximum standardized uptake value of ≥9.8, c-T4 status, c-M1 status, and non-surgery were negatively associated with overall survival (p<0.05). Multivariate analysis showed that ≥60 age, left hemithorax involvement, a maximum standardized uptake value of ≥9.8, c-M1 status, and a total lesion glycolysis of ≥180.2 g were negatively associated with overall survival (p<0.05). CONCLUSION: Metabolic parameters of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography have the potential to provide prognostic information for malignant pleural mesothelioma patients who are receiving surgery and/or chemotherapy. Bayçınar Medical Publishing 2021-01-13 /pmc/articles/PMC7970077/ /pubmed/33768986 http://dx.doi.org/10.5606/tgkdc.dergisi.2021.20432 Text en Copyright © 2021, Turkish Society of Cardiovascular Surgery http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Article Yenigün, Bülent Mustafa Kahya, Yusuf Soydal, Çiğdem Ata Tutkun, Nihal Kocaman, Gökhan Koçak, Emre Muhammed Özkan, Elgin Dizbay Sak, Serpil Kayı Cangır, Ayten The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma |
title | The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma |
title_full | The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma |
title_fullStr | The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma |
title_full_unstemmed | The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma |
title_short | The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma |
title_sort | prognostic value of 18f-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970077/ https://www.ncbi.nlm.nih.gov/pubmed/33768986 http://dx.doi.org/10.5606/tgkdc.dergisi.2021.20432 |
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