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HN-CNN: A Heterogeneous Network Based on Convolutional Neural Network for m(7) G Site Disease Association Prediction
N(7)-methylguanosine (m(7)G) is a typical positively charged RNA modification, playing a vital role in transcriptional regulation. m(7)G can affect the biological processes of mRNA and tRNA and has associations with multiple diseases including cancers. Wet-lab experiments are cost and time ineffecti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970120/ https://www.ncbi.nlm.nih.gov/pubmed/33747055 http://dx.doi.org/10.3389/fgene.2021.655284 |
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author | Zhang, Lin Chen, Jin Ma, Jiani Liu, Hui |
author_facet | Zhang, Lin Chen, Jin Ma, Jiani Liu, Hui |
author_sort | Zhang, Lin |
collection | PubMed |
description | N(7)-methylguanosine (m(7)G) is a typical positively charged RNA modification, playing a vital role in transcriptional regulation. m(7)G can affect the biological processes of mRNA and tRNA and has associations with multiple diseases including cancers. Wet-lab experiments are cost and time ineffective for the identification of disease-related m(7)G sites. Thus, a heterogeneous network method based on Convolutional Neural Networks (HN-CNN) has been proposed to predict unknown associations between m(7)G sites and diseases. HN-CNN constructs a heterogeneous network with m(7)G site similarity, disease similarity, and disease-associated m(7)G sites to formulate features for m(7)G site-disease pairs. Next, a convolutional neural network (CNN) obtains multidimensional and irrelevant features prominently. Finally, XGBoost is adopted to predict the association between m(7)G sites and diseases. The performance of HN-CNN is compared with Naive Bayes (NB), Random Forest (RF), Support Vector Machine (SVM), as well as Gradient Boosting Decision Tree (GBDT) through 10-fold cross-validation. The average AUC of HN-CNN is 0.827, which is superior to others. |
format | Online Article Text |
id | pubmed-7970120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79701202021-03-19 HN-CNN: A Heterogeneous Network Based on Convolutional Neural Network for m(7) G Site Disease Association Prediction Zhang, Lin Chen, Jin Ma, Jiani Liu, Hui Front Genet Genetics N(7)-methylguanosine (m(7)G) is a typical positively charged RNA modification, playing a vital role in transcriptional regulation. m(7)G can affect the biological processes of mRNA and tRNA and has associations with multiple diseases including cancers. Wet-lab experiments are cost and time ineffective for the identification of disease-related m(7)G sites. Thus, a heterogeneous network method based on Convolutional Neural Networks (HN-CNN) has been proposed to predict unknown associations between m(7)G sites and diseases. HN-CNN constructs a heterogeneous network with m(7)G site similarity, disease similarity, and disease-associated m(7)G sites to formulate features for m(7)G site-disease pairs. Next, a convolutional neural network (CNN) obtains multidimensional and irrelevant features prominently. Finally, XGBoost is adopted to predict the association between m(7)G sites and diseases. The performance of HN-CNN is compared with Naive Bayes (NB), Random Forest (RF), Support Vector Machine (SVM), as well as Gradient Boosting Decision Tree (GBDT) through 10-fold cross-validation. The average AUC of HN-CNN is 0.827, which is superior to others. Frontiers Media S.A. 2021-03-04 /pmc/articles/PMC7970120/ /pubmed/33747055 http://dx.doi.org/10.3389/fgene.2021.655284 Text en Copyright © 2021 Zhang, Chen, Ma and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Zhang, Lin Chen, Jin Ma, Jiani Liu, Hui HN-CNN: A Heterogeneous Network Based on Convolutional Neural Network for m(7) G Site Disease Association Prediction |
title | HN-CNN: A Heterogeneous Network Based on Convolutional Neural Network for m(7) G Site Disease Association Prediction |
title_full | HN-CNN: A Heterogeneous Network Based on Convolutional Neural Network for m(7) G Site Disease Association Prediction |
title_fullStr | HN-CNN: A Heterogeneous Network Based on Convolutional Neural Network for m(7) G Site Disease Association Prediction |
title_full_unstemmed | HN-CNN: A Heterogeneous Network Based on Convolutional Neural Network for m(7) G Site Disease Association Prediction |
title_short | HN-CNN: A Heterogeneous Network Based on Convolutional Neural Network for m(7) G Site Disease Association Prediction |
title_sort | hn-cnn: a heterogeneous network based on convolutional neural network for m(7) g site disease association prediction |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970120/ https://www.ncbi.nlm.nih.gov/pubmed/33747055 http://dx.doi.org/10.3389/fgene.2021.655284 |
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