Dose-response meta-analysis of arsenic exposure in drinking water and hypertension

BACKGROUND: Based on the cross-sectional and cohort studies, exposure to As via drinking water can cause hypertension. METHODS: We searched PubMed, ISI WOS, and Scopus for relevant studies up to 1 January 2018 using related keywords. The meta-analysis was done on 10 studies (n = 28255) that report O...

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Detalles Bibliográficos
Autores principales: Amiri, Afsaneh, Mokhayeri, Yaser, Mohammadi, Rasool, Karami, Mohammad Amin, Ghaderpoori, Mansour, Kamarehie, Bahram, Jafari, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970273/
https://www.ncbi.nlm.nih.gov/pubmed/33748480
http://dx.doi.org/10.1016/j.heliyon.2021.e06409
Descripción
Sumario:BACKGROUND: Based on the cross-sectional and cohort studies, exposure to As via drinking water can cause hypertension. METHODS: We searched PubMed, ISI WOS, and Scopus for relevant studies up to 1 January 2018 using related keywords. The meta-analysis was done on 10 studies (n = 28255) that report Odds Ratio for hypertension. The extracted ORs between As concentration and hypertension were pooled using random effect models. Study heterogeneity was analyzed using I(2). RESULTS: The estimated adjusted OR for association between As and hypertension was 1.44 (95% CI: 1.12, 1.84) with I(2) = 71%. Dose-Response analysis showed a linear relationship between As and hypertension (OR = 1.0008 95% CI: 1.0003, 1.001). In general, by increase of each unit in arsenic concentration, odds of the hypertension would increase as 0.08%. CONCLUSION: There was a significant relationship between As exposure and hypertension.

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