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A possible role for ST2 as prognostic biomarker for COVID-19
COVID-19 is a pandemic illness caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2). It has been estimated that 80% of subject infected are asymptomatic or have mild to moderate symptoms. Differently, in severe cases of COVID-19, cytokine storm, acute respiratory distress syndro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970796/ https://www.ncbi.nlm.nih.gov/pubmed/33746068 http://dx.doi.org/10.1016/j.vph.2021.106857 |
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author | Ragusa, Rosetta Basta, Giuseppina Del Turco, Serena Caselli, Chiara |
author_facet | Ragusa, Rosetta Basta, Giuseppina Del Turco, Serena Caselli, Chiara |
author_sort | Ragusa, Rosetta |
collection | PubMed |
description | COVID-19 is a pandemic illness caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2). It has been estimated that 80% of subject infected are asymptomatic or have mild to moderate symptoms. Differently, in severe cases of COVID-19, cytokine storm, acute respiratory distress syndrome (ARDS), severe systemic inflammatory response and cardiovascular diseases were observed Even if all molecular mechanisms leading to cardiovascular dysfunction in COVID-19 patients remain to be clarified, the evaluation of biomarkers of cardiac injury, stress and inflammation proved to be an excellent tool to identify the COVID-19 patients with worse outcome. However, the number of biomarkers used to manage COVID-19 patients is expected to increase with the increasing knowledge of the pathophysiology of the disease. It is our view that soluble suppressor of tumorigenicity 2 (sST2) can be used as biomarker in COVID-19. sST2 is routinely used as prognostic biomarker in patients with HF. Moreover, high circulating levels of sST2 have also been found in subjects with ARDS, pulmonary fibrosis and sepsis. Keeping in mind these considerations, in this review the possible mechanisms through which the SARS-CoV2 infection could damage the cardiovascular system were summarized and the possible role of sST2 in COVID-19 patients with CVD was discussed. |
format | Online Article Text |
id | pubmed-7970796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79707962021-03-19 A possible role for ST2 as prognostic biomarker for COVID-19 Ragusa, Rosetta Basta, Giuseppina Del Turco, Serena Caselli, Chiara Vascul Pharmacol Review COVID-19 is a pandemic illness caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2). It has been estimated that 80% of subject infected are asymptomatic or have mild to moderate symptoms. Differently, in severe cases of COVID-19, cytokine storm, acute respiratory distress syndrome (ARDS), severe systemic inflammatory response and cardiovascular diseases were observed Even if all molecular mechanisms leading to cardiovascular dysfunction in COVID-19 patients remain to be clarified, the evaluation of biomarkers of cardiac injury, stress and inflammation proved to be an excellent tool to identify the COVID-19 patients with worse outcome. However, the number of biomarkers used to manage COVID-19 patients is expected to increase with the increasing knowledge of the pathophysiology of the disease. It is our view that soluble suppressor of tumorigenicity 2 (sST2) can be used as biomarker in COVID-19. sST2 is routinely used as prognostic biomarker in patients with HF. Moreover, high circulating levels of sST2 have also been found in subjects with ARDS, pulmonary fibrosis and sepsis. Keeping in mind these considerations, in this review the possible mechanisms through which the SARS-CoV2 infection could damage the cardiovascular system were summarized and the possible role of sST2 in COVID-19 patients with CVD was discussed. Elsevier Inc. 2021-06 2021-03-18 /pmc/articles/PMC7970796/ /pubmed/33746068 http://dx.doi.org/10.1016/j.vph.2021.106857 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Ragusa, Rosetta Basta, Giuseppina Del Turco, Serena Caselli, Chiara A possible role for ST2 as prognostic biomarker for COVID-19 |
title | A possible role for ST2 as prognostic biomarker for COVID-19 |
title_full | A possible role for ST2 as prognostic biomarker for COVID-19 |
title_fullStr | A possible role for ST2 as prognostic biomarker for COVID-19 |
title_full_unstemmed | A possible role for ST2 as prognostic biomarker for COVID-19 |
title_short | A possible role for ST2 as prognostic biomarker for COVID-19 |
title_sort | possible role for st2 as prognostic biomarker for covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970796/ https://www.ncbi.nlm.nih.gov/pubmed/33746068 http://dx.doi.org/10.1016/j.vph.2021.106857 |
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