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Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation

The objective of this study was to compare three different heat transfer models for radiofrequency ablation of in vivo liver tissue using a cooled electrode and three different voltage levels. The comparison was between the simplest but less realistic Pennes’ equation and two porous media-based mode...

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Autores principales: Tucci, Claudio, Trujillo, Macarena, Berjano, Enrique, Iasiello, Marcello, Andreozzi, Assunta, Vanoli, Giuseppe Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970869/
https://www.ncbi.nlm.nih.gov/pubmed/33674658
http://dx.doi.org/10.1038/s41598-021-84546-6
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author Tucci, Claudio
Trujillo, Macarena
Berjano, Enrique
Iasiello, Marcello
Andreozzi, Assunta
Vanoli, Giuseppe Peter
author_facet Tucci, Claudio
Trujillo, Macarena
Berjano, Enrique
Iasiello, Marcello
Andreozzi, Assunta
Vanoli, Giuseppe Peter
author_sort Tucci, Claudio
collection PubMed
description The objective of this study was to compare three different heat transfer models for radiofrequency ablation of in vivo liver tissue using a cooled electrode and three different voltage levels. The comparison was between the simplest but less realistic Pennes’ equation and two porous media-based models, i.e. the Local Thermal Non-Equilibrium (LTNE) equations and Local Thermal Equilibrium (LTE) equation, both modified to take into account two-phase water vaporization (tissue and blood). Different blood volume fractions in liver were considered and the blood velocity was modeled to simulate a vascular network. Governing equations with the appropriate boundary conditions were solved with Comsol Multiphysics finite-element code. The results in terms of coagulation transverse diameters and temperature distributions at the end of the application showed significant differences, especially between Pennes and the modified LTNE and LTE models. The new modified porous media-based models covered the ranges found in the few in vivo experimental studies in the literature and they were closer to the published results with similar in vivo protocol. The outcomes highlight the importance of considering the three models in the future in order to improve thermal ablation protocols and devices and adapt the model to different organs and patient profiles.
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spelling pubmed-79708692021-03-19 Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation Tucci, Claudio Trujillo, Macarena Berjano, Enrique Iasiello, Marcello Andreozzi, Assunta Vanoli, Giuseppe Peter Sci Rep Article The objective of this study was to compare three different heat transfer models for radiofrequency ablation of in vivo liver tissue using a cooled electrode and three different voltage levels. The comparison was between the simplest but less realistic Pennes’ equation and two porous media-based models, i.e. the Local Thermal Non-Equilibrium (LTNE) equations and Local Thermal Equilibrium (LTE) equation, both modified to take into account two-phase water vaporization (tissue and blood). Different blood volume fractions in liver were considered and the blood velocity was modeled to simulate a vascular network. Governing equations with the appropriate boundary conditions were solved with Comsol Multiphysics finite-element code. The results in terms of coagulation transverse diameters and temperature distributions at the end of the application showed significant differences, especially between Pennes and the modified LTNE and LTE models. The new modified porous media-based models covered the ranges found in the few in vivo experimental studies in the literature and they were closer to the published results with similar in vivo protocol. The outcomes highlight the importance of considering the three models in the future in order to improve thermal ablation protocols and devices and adapt the model to different organs and patient profiles. Nature Publishing Group UK 2021-03-05 /pmc/articles/PMC7970869/ /pubmed/33674658 http://dx.doi.org/10.1038/s41598-021-84546-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tucci, Claudio
Trujillo, Macarena
Berjano, Enrique
Iasiello, Marcello
Andreozzi, Assunta
Vanoli, Giuseppe Peter
Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title_full Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title_fullStr Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title_full_unstemmed Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title_short Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title_sort pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970869/
https://www.ncbi.nlm.nih.gov/pubmed/33674658
http://dx.doi.org/10.1038/s41598-021-84546-6
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