Cargando…

Omics data integration identifies ELOVL7 and MMD gene regions as novel loci for adalimumab response in patients with Crohn’s disease

Response to anti-TNF therapy is of pivotal importance in patients with Crohn’s disease (CD). Here we integrated our and previously reported PBMC derived transcriptomic and genomic data for identification of biomarkers for discrimination between responders and non-responders to anti-TNF therapy. CD p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gorenjak, Mario, Zupin, Mateja, Jezernik, Gregor, Skok, Pavel, Potočnik, Uroš
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970911/ https://www.ncbi.nlm.nih.gov/pubmed/33750834 http://dx.doi.org/10.1038/s41598-021-84909-z

Ejemplares similares

Identification of Novel Loci Involved in Adalimumab Response in Crohn’s Disease Patients Using Integration of Genome Profiling and Isoform-Level Immune-Cell Deconvoluted Transcriptome Profiling of Colon Tissue
por: Gorenjak, Mario, et al.
Publicado: (2022)

MIF Variant rs755622 Is Associated with Severe Crohn’s Disease and Better Response to Anti-TNF Adalimumab Therapy
por: Jezernik, Gregor, et al.
Publicado: (2023)

Gene Ontology Analysis Highlights Biological Processes Influencing Non-Response to Anti-TNF Therapy in Rheumatoid Arthritis
por: Jezernik, Gregor, et al.
Publicado: (2022)

Meta-Analytic Comparison of Global RNA Transcriptomes of Acute and Chronic Myeloid Leukemia Cells Reveals Novel Gene Candidates Governing Myeloid Malignancies
por: Jurgec, Staša, et al.
Publicado: (2022)

MFUM-BrTNBC-1, a Newly Established Patient-Derived Triple-Negative Breast Cancer Cell Line: Molecular Characterisation, Genetic Stability, and Comprehensive Comparison with Commercial Breast Cancer Cell Lines
por: Skok, Kristijan, et al.
Publicado: (2021)

Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in Psoriasis
por: Krušič, Martina, et al.
Publicado: (2023)

Molecular Genetic Architecture of Monogenic Pediatric IBD Differs from Complex Pediatric and Adult IBD
por: Jezernik, Gregor, et al.
Publicado: (2020)

Dual Effect of Combined Metformin and 2-Deoxy-D-Glucose Treatment on Mitochondrial Biogenesis and PD-L1 Expression in Triple-Negative Breast Cancer Cells
por: Repas, Jernej, et al.
Publicado: (2022)

Chinese expert consensus on the treatment of MMD
por: Bao, Xiang-Yang, et al.
Publicado: (2023)

Dysregulation of Synaptic Signaling Genes Is Involved in Biology of Uterine Leiomyoma
por: Krsteski, Jovan, et al.
Publicado: (2021)

Glioblastoma Multiforme Tumors in Women Have a Lower Expression of Fatty Acid Elongases ELOVL2, ELOVL5, ELOVL6, and ELOVL7 than in Men
por: Korbecki, Jan, et al.
Publicado: (2022)

Pre-treatment Risk Assessment of Women with Endometrial Cancer: Differences in Outcomes of Molecular and Clinical Classifications in The Slovenian Patient Cohort
por: Knez, Jure, et al.
Publicado: (2021)

Adalimumab in Crohn’s disease
por: Van Assche, Gert, et al.
Publicado: (2007)

De novo mutation in KITLG gene causes a variant of Familial Progressive Hyper‐ and Hypo‐pigmentation (FPHH)
por: Gorenjak, Mario, et al.
Publicado: (2021)

Cholecalciferol Supplementation Induced Up-Regulation of SARAF Gene and Down-Regulated miR-155-5p Expression in Slovenian Patients with Multiple Sclerosis
por: Gselman, Saša, et al.
Publicado: (2023)

Transcriptomics of receptive endometrium in women with sonographic features of adenomyosis
por: Prašnikar, Erika, et al.
Publicado: (2022)

Adalimumab for the treatment of Crohn’s disease
por: Cassinotti, Andrea, et al.
Publicado: (2008)

Pre-Treatment Biomarkers of Anti-Tumour Necrosis Factor Therapy Response in Crohn’s Disease—A Systematic Review and Gene Ontology Analysis
por: Gole, Boris, et al.
Publicado: (2019)

The impact of COVID‐19 on multi‐month dispensing (MMD) policies for antiretroviral therapy (ART) and MMD uptake in 21 PEPFAR‐supported countries: a multi‐country analysis
por: Bailey, Lauren E., et al.
Publicado: (2021)

Adalimumab Therapy Improves Intestinal Dysbiosis in Crohn’s Disease
por: Ribaldone, Davide Giuseppe, et al.
Publicado: (2019)

Adalimumab for the treatment of fistulas in patients with Crohn’s disease
por: Colombel, J-F, et al.
Publicado: (2009)

Management of Crohn’s disease in poor responders to adalimumab
por: de Boer, Nanne KH, et al.
Publicado: (2014)

Efficacy of Adalimumab in Korean Patients with Crohn’s Disease
por: Sohn, Il Woong, et al.
Publicado: (2016)

A Meta-Analysis of Adalimumab for Fistula in Crohn's Disease
por: Fu, Yin-mei, et al.
Publicado: (2017)

Difficult-to-treat-pediatric Crohn’s disease: focus on adalimumab
por: Zeisler, Bella, et al.
Publicado: (2015)

Leukocytoclastic Vasculitis Associated with Adalimumab Therapy for Crohn’s Disease
por: Xu, Lankai Cathy, et al.
Publicado: (2023)

The Swedish translation and cultural adaptation of the Measure of Moral Distress for Healthcare Professionals (MMD-HP)
por: Fischer-Grönlund, Catarina, et al.
Publicado: (2021)

Applying MMD Data Mining to Match Network Traffic for Stepping-Stone Intrusion Detection
por: Yang, Jianhua, et al.
Publicado: (2021)

Psychometric testing of the Swedish version of the measure of moral distress for healthcare professionals (MMD-HP)
por: Fischer-Grönlund, Catarina, et al.
Publicado: (2023)

Structure and function analyses of the Mmd2 gene in pacific white shrimp Litopenaeus vannamei
por: Si, Shuqing, et al.
Publicado: (2023)

Adalimumab Effectiveness Up to Six Years in Adalimumab-naïve Patients with Crohn’s Disease: Results of the PYRAMID Registry
por: Loftus, Edward V, et al.
Publicado: (2019)

Therapeutic Role of ELOVL in Neurological Diseases
por: Siddiqui, Arif Jamal, et al.
Publicado: (2023)

Mesenteric Fibromatosis in Crohn's Disease as a Potential Effect of Adalimumab
por: Abdelqader, Abdelhai, et al.
Publicado: (2016)

Listeria Monocytogenes Brain Abscess in Crohn's Disease Treated with Adalimumab
por: Atsawarungruangkit, Amporn, et al.
Publicado: (2017)

Adalimumab or infliximab: which is better for perianal fistula in Crohn's disease?
por: Im, Jong Pil
Publicado: (2017)

MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylation
por: Bhardwaj, Abhishek, et al.
Publicado: (2022)

MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2
por: Hu, Shaojun, et al.
Publicado: (2022)

MS1/MMD1 homologues in the moss Physcomitrium patens are required for male and female gametogenesis
por: Landberg, Katarina, et al.
Publicado: (2022)

Risk factors for wound healing complications after revascularization for MMD with complete Y-shaped incision
por: Wang, Chenchao, et al.
Publicado: (2023)

Dominant Elongase Activity of Elovl5a but Higher Expression of Elovl5b in Common Carp (Cyprinus carpio)
por: Zhao, Ran, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_46g4perv6vfv6svdp84kvc3viv