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Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach
Multifunctional nanoparticles are discussed as versatile probes for homogeneous immunoassays for in-vitro diagnostics. Top-down fabrication allows to combine and tailor magnetic and plasmonic anisotropic properties. The combination of nanoimprint lithography, thin film deposition, and lift-off proce...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971043/ https://www.ncbi.nlm.nih.gov/pubmed/33727602 http://dx.doi.org/10.1038/s41598-021-85524-8 |
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author | Brueckl, Hubert Shoshi, Astrit Schrittwieser, Stefan Schmid, Barbara Schneeweiss, Pia Mitteramskogler, Tina Haslinger, Michael J. Muehlberger, Michael Schotter, Joerg |
author_facet | Brueckl, Hubert Shoshi, Astrit Schrittwieser, Stefan Schmid, Barbara Schneeweiss, Pia Mitteramskogler, Tina Haslinger, Michael J. Muehlberger, Michael Schotter, Joerg |
author_sort | Brueckl, Hubert |
collection | PubMed |
description | Multifunctional nanoparticles are discussed as versatile probes for homogeneous immunoassays for in-vitro diagnostics. Top-down fabrication allows to combine and tailor magnetic and plasmonic anisotropic properties. The combination of nanoimprint lithography, thin film deposition, and lift-off processing provides a top-down fabrication platform, which is both flexible and reliable. Here, we discuss the material compositions and geometrical designs of monodisperse multicomponent nanoparticles and their consequences on optical and magnetic properties. The rotational hydrodynamics of nanoparticles is measured and considered under the influence of magnetic shape anisotropy in the framework of the Stoner-Wohlfarth theory. The plasmon-optical properties are explained by discrete-dipole finite-element simulations. Rotational dynamical measurements of imprinted nanoprobes for two test proteins demonstrate the applicability as highly sensitive biomolecular nanoprobes. |
format | Online Article Text |
id | pubmed-7971043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79710432021-03-19 Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach Brueckl, Hubert Shoshi, Astrit Schrittwieser, Stefan Schmid, Barbara Schneeweiss, Pia Mitteramskogler, Tina Haslinger, Michael J. Muehlberger, Michael Schotter, Joerg Sci Rep Article Multifunctional nanoparticles are discussed as versatile probes for homogeneous immunoassays for in-vitro diagnostics. Top-down fabrication allows to combine and tailor magnetic and plasmonic anisotropic properties. The combination of nanoimprint lithography, thin film deposition, and lift-off processing provides a top-down fabrication platform, which is both flexible and reliable. Here, we discuss the material compositions and geometrical designs of monodisperse multicomponent nanoparticles and their consequences on optical and magnetic properties. The rotational hydrodynamics of nanoparticles is measured and considered under the influence of magnetic shape anisotropy in the framework of the Stoner-Wohlfarth theory. The plasmon-optical properties are explained by discrete-dipole finite-element simulations. Rotational dynamical measurements of imprinted nanoprobes for two test proteins demonstrate the applicability as highly sensitive biomolecular nanoprobes. Nature Publishing Group UK 2021-03-16 /pmc/articles/PMC7971043/ /pubmed/33727602 http://dx.doi.org/10.1038/s41598-021-85524-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Brueckl, Hubert Shoshi, Astrit Schrittwieser, Stefan Schmid, Barbara Schneeweiss, Pia Mitteramskogler, Tina Haslinger, Michael J. Muehlberger, Michael Schotter, Joerg Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach |
title | Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach |
title_full | Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach |
title_fullStr | Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach |
title_full_unstemmed | Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach |
title_short | Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach |
title_sort | nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971043/ https://www.ncbi.nlm.nih.gov/pubmed/33727602 http://dx.doi.org/10.1038/s41598-021-85524-8 |
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