NNT in NSCLC: No need to worry?

In this study, Ward et al. (https://doi.org/10.1084/jem.20191689) provide exciting evidence that nucleotide nicotinamide transhydrogenase (NNT), a mitochondrial matrix–located enzyme harnessing the proton gradient to generate NADPH using NADH, markedly contributes to non-small cell lung carcinoma (N...

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Detalles Bibliográficos
Autor principal: Conrad, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971126/
https://www.ncbi.nlm.nih.gov/pubmed/32294154
http://dx.doi.org/10.1084/jem.20200310
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author Conrad, Marcus
author_facet Conrad, Marcus
author_sort Conrad, Marcus
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description In this study, Ward et al. (https://doi.org/10.1084/jem.20191689) provide exciting evidence that nucleotide nicotinamide transhydrogenase (NNT), a mitochondrial matrix–located enzyme harnessing the proton gradient to generate NADPH using NADH, markedly contributes to non-small cell lung carcinoma (NSCLC), which is abrogated in the murine C57BL/6J background, a strain known to be deficient in NNT.
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spelling pubmed-79711262021-03-26 NNT in NSCLC: No need to worry? Conrad, Marcus J Exp Med Insights In this study, Ward et al. (https://doi.org/10.1084/jem.20191689) provide exciting evidence that nucleotide nicotinamide transhydrogenase (NNT), a mitochondrial matrix–located enzyme harnessing the proton gradient to generate NADPH using NADH, markedly contributes to non-small cell lung carcinoma (NSCLC), which is abrogated in the murine C57BL/6J background, a strain known to be deficient in NNT. Rockefeller University Press 2020-04-15 /pmc/articles/PMC7971126/ /pubmed/32294154 http://dx.doi.org/10.1084/jem.20200310 Text en © 2020 Conrad http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Conrad, Marcus
NNT in NSCLC: No need to worry?
title NNT in NSCLC: No need to worry?
title_full NNT in NSCLC: No need to worry?
title_fullStr NNT in NSCLC: No need to worry?
title_full_unstemmed NNT in NSCLC: No need to worry?
title_short NNT in NSCLC: No need to worry?
title_sort nnt in nsclc: no need to worry?
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971126/
https://www.ncbi.nlm.nih.gov/pubmed/32294154
http://dx.doi.org/10.1084/jem.20200310
work_keys_str_mv AT conradmarcus nntinnsclcnoneedtoworry

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