ACKR4 restrains antitumor immunity by regulating CCL21

Current immunotherapies involving CD8(+) T cell responses show remarkable promise, but their efficacy in many solid tumors is limited, in part due to the low frequency of tumor-specific T cells in the tumor microenvironment (TME). Here, we identified a role for host atypical chemokine receptor 4 (AC...

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Detalles Bibliográficos
Autores principales: Whyte, Carly E., Osman, Maleika, Kara, Ervin E., Abbott, Caitlin, Foeng, Jade, McKenzie, Duncan R., Fenix, Kevin A., Harata-Lee, Yuka, Foyle, Kerrie L., Boyle, Sarah T., Kochetkova, Marina, Aguilera, Amelia Roman, Hou, Jiajie, Li, Xian-Yang, Armstrong, Mark A., Pederson, Stephen M., Comerford, Iain, Smyth, Mark J., McColl, Shaun R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971131/
https://www.ncbi.nlm.nih.gov/pubmed/32289156
http://dx.doi.org/10.1084/jem.20190634

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