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PRDM16 suppresses HIF-targeted gene expression in kidney cancer

Analysis of transcriptomic data demonstrates extensive epigenetic gene silencing of the transcription factor PRDM16 in renal cancer. We show that restoration of PRDM16 in RCC cells suppresses in vivo tumor growth. RNaseq analysis reveals that PRDM16 imparts a predominantly repressive effect on the R...

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Detalles Bibliográficos
Autores principales:	Kundu, Anirban, Nam, Hyeyoung, Shelar, Sandeep, Chandrashekar, Darshan S., Brinkley, Garrett, Karki, Suman, Mitchell, Tanecia, Livi, Carolina B., Buckhaults, Phillip, Kirkman, Richard, Tang, Yawen, Rowe, Glenn C., Wei, Shi, Varambally, Sooryanarayana, Sudarshan, Sunil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971134/ https://www.ncbi.nlm.nih.gov/pubmed/32251515 http://dx.doi.org/10.1084/jem.20191005

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