Endothelial mTOR maintains hematopoiesis during aging

Aging leads to a decline in hematopoietic stem and progenitor cell (HSPC) function. We recently discovered that aging of bone marrow endothelial cells (BMECs) leads to an altered crosstalk between the BMEC niche and HSPCs, which instructs young HSPCs to behave as aged HSPCs. Here, we demonstrate agi...

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Detalles Bibliográficos
Autores principales: Ramalingam, Pradeep, Poulos, Michael G., Gutkin, Michael C., Katsnelson, Lizabeth, Freire, Ana G., Lazzari, Elisa, Butler, Jason M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971143/
https://www.ncbi.nlm.nih.gov/pubmed/32289154
http://dx.doi.org/10.1084/jem.20191212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971143/
https://www.ncbi.nlm.nih.gov/pubmed/32289154
http://dx.doi.org/10.1084/jem.20191212

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