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IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt

Background: Psoriatic arthritis (PsA) is a chronic inflammatory joint disease within the spondyloarthritis spectrum. IL-12p40/IL-23p40 blockade reduces PsA disease activity, but its impact on synovial inflammation remains unclear. Objectives: To investigate the cellular and molecular pathways affect...

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Detalles Bibliográficos
Autores principales:	Fiechter, Renée H., de Jong, Henriëtte M., van Mens, Leonieke J. J., Fluri, Inka A., Tas, Sander W., Baeten, Dominique L. P., Yeremenko, Nataliya G., van de Sande, Marleen G. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971179/ https://www.ncbi.nlm.nih.gov/pubmed/33746955 http://dx.doi.org/10.3389/fimmu.2021.611656

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