The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation

Neuroblastoma is a highly metastatic tumor that emerges from neural crest cell progenitors. Focal Adhesion Kinase (FAK) is a regulator of cell migration that binds to the receptor Neogenin-1 and is upregulated in neuroblastoma. Here, we show that Netrin-1 ligand binding to Neogenin-1 leads to FAK au...

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Detalles Bibliográficos
Autores principales: Villanueva, Andrea A., Sanchez-Gomez, Pilar, Muñoz-Palma, Ernesto, Puvogel, Sofía, Casas, Bárbara S., Arriagada, Cecilia, Peña-Villalobos, Isaac, Lois, Pablo, Ramírez Orellana, Manuel, Lubieniecki, Fabiana, Casco Claro, Fernando, Gallegos, Iván, García-Castro, Javier, Torres, Vicente A., Palma, Verónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971226/
https://www.ncbi.nlm.nih.gov/pubmed/33724150
http://dx.doi.org/10.1080/19336918.2021.1892397

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