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First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode()
Favipiravir, a promising antiviral agent, is undergoing clinical trials for the potential treatment of the novel coronavirus disease 2019 (COVID-19). This is the first report for the electrochemical activity of favipiravir and its electroanalytical sensing. For this purpose, the effect of cationic s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971419/ https://www.ncbi.nlm.nih.gov/pubmed/33867032 http://dx.doi.org/10.1016/j.aca.2021.338418 |
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author | Allahverdiyeva, Shabnam Yunusoğlu, Oruc Yardım, Yavuz Şentürk, Zühre |
author_facet | Allahverdiyeva, Shabnam Yunusoğlu, Oruc Yardım, Yavuz Şentürk, Zühre |
author_sort | Allahverdiyeva, Shabnam |
collection | PubMed |
description | Favipiravir, a promising antiviral agent, is undergoing clinical trials for the potential treatment of the novel coronavirus disease 2019 (COVID-19). This is the first report for the electrochemical activity of favipiravir and its electroanalytical sensing. For this purpose, the effect of cationic surfactant, CTAB was demonstrated on the enhanced accumulation of favipiravir at the surface of cathodically pretreated boron-doped diamond (CPT-BDD) electrode. At first, the electrochemical properties of favipiravir were investigated in the surfactant-free solutions by the means of cyclic voltammetry. The compound presented a single oxidation step which is irreversible and adsorption controlled. A systematic study of various operational conditions, such as electrode pretreatment, pH of the supporting electrolyte, concentration of CTAB, accumulation variables, and instrumental parameters on the adsorptive stripping response, was examined using square-wave voltammetry. An oxidation signal at around +1.21 V in Britton-Robinson buffer at pH 8.0 containing 6 × 10(−4) M CTAB allowed to the adsorptive stripping voltammetric determination of favipiravir (after 60 s accumulation step at open-circuit condition). The process could be used in the concentration range with two linear segments of 0.01–0.1 μg mL(−1) (6.4 × 10(−8)-6.4 × 10(−7) M) and 0.1–20.0 μg mL(−1) (6.4 × 10(−7)-1.3 × 10(−4) M). The limit of detection values were found to be 0.0028 μg mL(−1) (1.8 × 10(−8) M), and 0.023 μg mL(−1) (1.5 × 10(−7) M) for the first and second segments of calibration graph, respectively. The feasibility of developed methodology was tested to the analysis of the commercial tablet formulations and model human urine samples. |
format | Online Article Text |
id | pubmed-7971419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79714192021-03-19 First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode() Allahverdiyeva, Shabnam Yunusoğlu, Oruc Yardım, Yavuz Şentürk, Zühre Anal Chim Acta Article Favipiravir, a promising antiviral agent, is undergoing clinical trials for the potential treatment of the novel coronavirus disease 2019 (COVID-19). This is the first report for the electrochemical activity of favipiravir and its electroanalytical sensing. For this purpose, the effect of cationic surfactant, CTAB was demonstrated on the enhanced accumulation of favipiravir at the surface of cathodically pretreated boron-doped diamond (CPT-BDD) electrode. At first, the electrochemical properties of favipiravir were investigated in the surfactant-free solutions by the means of cyclic voltammetry. The compound presented a single oxidation step which is irreversible and adsorption controlled. A systematic study of various operational conditions, such as electrode pretreatment, pH of the supporting electrolyte, concentration of CTAB, accumulation variables, and instrumental parameters on the adsorptive stripping response, was examined using square-wave voltammetry. An oxidation signal at around +1.21 V in Britton-Robinson buffer at pH 8.0 containing 6 × 10(−4) M CTAB allowed to the adsorptive stripping voltammetric determination of favipiravir (after 60 s accumulation step at open-circuit condition). The process could be used in the concentration range with two linear segments of 0.01–0.1 μg mL(−1) (6.4 × 10(−8)-6.4 × 10(−7) M) and 0.1–20.0 μg mL(−1) (6.4 × 10(−7)-1.3 × 10(−4) M). The limit of detection values were found to be 0.0028 μg mL(−1) (1.8 × 10(−8) M), and 0.023 μg mL(−1) (1.5 × 10(−7) M) for the first and second segments of calibration graph, respectively. The feasibility of developed methodology was tested to the analysis of the commercial tablet formulations and model human urine samples. Elsevier B.V. 2021-05-15 2021-03-18 /pmc/articles/PMC7971419/ /pubmed/33867032 http://dx.doi.org/10.1016/j.aca.2021.338418 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Allahverdiyeva, Shabnam Yunusoğlu, Oruc Yardım, Yavuz Şentürk, Zühre First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode() |
title | First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode() |
title_full | First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode() |
title_fullStr | First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode() |
title_full_unstemmed | First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode() |
title_short | First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode() |
title_sort | first electrochemical evaluation of favipiravir used as an antiviral option in the treatment of covid-19: a study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971419/ https://www.ncbi.nlm.nih.gov/pubmed/33867032 http://dx.doi.org/10.1016/j.aca.2021.338418 |
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