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Aging steepens the slope of power spectrum density of 30-minute continuous blood pressure recording in healthy human subjects

BACKGROUND: The increase of blood pressure (BP) variability (BPV) is recognized as an important additional cardiovascular risk factor in both normotensive subjects and hypertensive patients. Aging-induced atherosclerosis and autonomic dysfunction impair the baroreflex and, in turn, augment 24-hour B...

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Autores principales: Mano, Jumpei, Saku, Keita, Kinoshita, Hiroyuki, Mannoji, Hiroshi, Kanaya, Shigehiko, Sunagawa, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971546/
https://www.ncbi.nlm.nih.gov/pubmed/33735286
http://dx.doi.org/10.1371/journal.pone.0248428
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author Mano, Jumpei
Saku, Keita
Kinoshita, Hiroyuki
Mannoji, Hiroshi
Kanaya, Shigehiko
Sunagawa, Kenji
author_facet Mano, Jumpei
Saku, Keita
Kinoshita, Hiroyuki
Mannoji, Hiroshi
Kanaya, Shigehiko
Sunagawa, Kenji
author_sort Mano, Jumpei
collection PubMed
description BACKGROUND: The increase of blood pressure (BP) variability (BPV) is recognized as an important additional cardiovascular risk factor in both normotensive subjects and hypertensive patients. Aging-induced atherosclerosis and autonomic dysfunction impair the baroreflex and, in turn, augment 24-hour BPV. In small and large animal experiments, impaired baroreflex steepens the slope of the power spectrum density (PSD) of continuous BP in the frequency range of 0.01 to 0.1 Hz. Although the repeated oscillometric BP recording over 24 hours or longer is a prerequisite to quantify BPV in humans, how the very short-term continuous BP recording reflects BPV remains unknown. This study aimed to evaluate the impact of aging on the very short-term (30-min) BPV in healthy human subjects by frequency analysis. METHODS: We recorded continuous BP tonometrically for 30 min in 56 healthy subjects aged between 28 and 85 years. Considering the frequency-dependence of the baroreflex dynamic function, we estimated the PSD of BP in the frequency range of 0.01 to 0.1 Hz, and compared the characteristics of PSD among four age groups (26–40, 41–55, 56–70 and 71–85 years). RESULTS: Aging did not significantly alter mean and standard deviation (SD) of BP among four age groups. PSD was nearly flat around 0.01 Hz and decreased gradually as the frequency increased. The slope of PSD between 0.01 and 0.1 Hz was steeper in older subjects (71 years or older) than in younger subjects (55 years or younger) (p < 0.05). CONCLUSIONS: Aging steepened the slope of PSD of BP between 0.01 and 0.1 Hz. This phenomenon may partly be related to the deterioration of the baroreflex in older subjects. Our proposed method to evaluate very short-term continuous BP recordings may contribute to the stratification of BPV.
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spelling pubmed-79715462021-03-31 Aging steepens the slope of power spectrum density of 30-minute continuous blood pressure recording in healthy human subjects Mano, Jumpei Saku, Keita Kinoshita, Hiroyuki Mannoji, Hiroshi Kanaya, Shigehiko Sunagawa, Kenji PLoS One Research Article BACKGROUND: The increase of blood pressure (BP) variability (BPV) is recognized as an important additional cardiovascular risk factor in both normotensive subjects and hypertensive patients. Aging-induced atherosclerosis and autonomic dysfunction impair the baroreflex and, in turn, augment 24-hour BPV. In small and large animal experiments, impaired baroreflex steepens the slope of the power spectrum density (PSD) of continuous BP in the frequency range of 0.01 to 0.1 Hz. Although the repeated oscillometric BP recording over 24 hours or longer is a prerequisite to quantify BPV in humans, how the very short-term continuous BP recording reflects BPV remains unknown. This study aimed to evaluate the impact of aging on the very short-term (30-min) BPV in healthy human subjects by frequency analysis. METHODS: We recorded continuous BP tonometrically for 30 min in 56 healthy subjects aged between 28 and 85 years. Considering the frequency-dependence of the baroreflex dynamic function, we estimated the PSD of BP in the frequency range of 0.01 to 0.1 Hz, and compared the characteristics of PSD among four age groups (26–40, 41–55, 56–70 and 71–85 years). RESULTS: Aging did not significantly alter mean and standard deviation (SD) of BP among four age groups. PSD was nearly flat around 0.01 Hz and decreased gradually as the frequency increased. The slope of PSD between 0.01 and 0.1 Hz was steeper in older subjects (71 years or older) than in younger subjects (55 years or younger) (p < 0.05). CONCLUSIONS: Aging steepened the slope of PSD of BP between 0.01 and 0.1 Hz. This phenomenon may partly be related to the deterioration of the baroreflex in older subjects. Our proposed method to evaluate very short-term continuous BP recordings may contribute to the stratification of BPV. Public Library of Science 2021-03-18 /pmc/articles/PMC7971546/ /pubmed/33735286 http://dx.doi.org/10.1371/journal.pone.0248428 Text en © 2021 Mano et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mano, Jumpei
Saku, Keita
Kinoshita, Hiroyuki
Mannoji, Hiroshi
Kanaya, Shigehiko
Sunagawa, Kenji
Aging steepens the slope of power spectrum density of 30-minute continuous blood pressure recording in healthy human subjects
title Aging steepens the slope of power spectrum density of 30-minute continuous blood pressure recording in healthy human subjects
title_full Aging steepens the slope of power spectrum density of 30-minute continuous blood pressure recording in healthy human subjects
title_fullStr Aging steepens the slope of power spectrum density of 30-minute continuous blood pressure recording in healthy human subjects
title_full_unstemmed Aging steepens the slope of power spectrum density of 30-minute continuous blood pressure recording in healthy human subjects
title_short Aging steepens the slope of power spectrum density of 30-minute continuous blood pressure recording in healthy human subjects
title_sort aging steepens the slope of power spectrum density of 30-minute continuous blood pressure recording in healthy human subjects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971546/
https://www.ncbi.nlm.nih.gov/pubmed/33735286
http://dx.doi.org/10.1371/journal.pone.0248428
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