IgLON 5 Antibody Syndrome: Isolated Case of a Patient With Indolent Disease Progression and Unusual MRI Findings

IgLON-5 antibody syndrome has a myriad of clinical presentations, including gait instability, movement disorders, abnormal eye movements, bulbar symptoms, sleep disorders, neuropsychiatric symptoms, dysautonomia, and peripheral neuropathy. Abnormal magnetic resonance imaging (MRI) findings have also...

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Detalles Bibliográficos
Autores principales: Park, Sihyeong, Doan, Jonathan, Sheikh, Irfan, Sheikh, Ajaz A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971709/
https://www.ncbi.nlm.nih.gov/pubmed/33754109
http://dx.doi.org/10.7759/cureus.13386
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author Park, Sihyeong
Doan, Jonathan
Sheikh, Irfan
Sheikh, Ajaz A
author_facet Park, Sihyeong
Doan, Jonathan
Sheikh, Irfan
Sheikh, Ajaz A
author_sort Park, Sihyeong
collection PubMed
description IgLON-5 antibody syndrome has a myriad of clinical presentations, including gait instability, movement disorders, abnormal eye movements, bulbar symptoms, sleep disorders, neuropsychiatric symptoms, dysautonomia, and peripheral neuropathy. Abnormal magnetic resonance imaging (MRI) findings have also been reported such as leukoariotic changes and cerebral and cerebellar atrophy. We present a case of IgLON-5 antibody syndrome with a unique MRI finding of persistent leptomeningeal enhancement. A close follow-up would be warranted as the progression of the disease may be indolent.
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spelling pubmed-79717092021-03-21 IgLON 5 Antibody Syndrome: Isolated Case of a Patient With Indolent Disease Progression and Unusual MRI Findings Park, Sihyeong Doan, Jonathan Sheikh, Irfan Sheikh, Ajaz A Cureus Neurology IgLON-5 antibody syndrome has a myriad of clinical presentations, including gait instability, movement disorders, abnormal eye movements, bulbar symptoms, sleep disorders, neuropsychiatric symptoms, dysautonomia, and peripheral neuropathy. Abnormal magnetic resonance imaging (MRI) findings have also been reported such as leukoariotic changes and cerebral and cerebellar atrophy. We present a case of IgLON-5 antibody syndrome with a unique MRI finding of persistent leptomeningeal enhancement. A close follow-up would be warranted as the progression of the disease may be indolent. Cureus 2021-02-17 /pmc/articles/PMC7971709/ /pubmed/33754109 http://dx.doi.org/10.7759/cureus.13386 Text en Copyright © 2021, Park et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Park, Sihyeong
Doan, Jonathan
Sheikh, Irfan
Sheikh, Ajaz A
IgLON 5 Antibody Syndrome: Isolated Case of a Patient With Indolent Disease Progression and Unusual MRI Findings
title IgLON 5 Antibody Syndrome: Isolated Case of a Patient With Indolent Disease Progression and Unusual MRI Findings
title_full IgLON 5 Antibody Syndrome: Isolated Case of a Patient With Indolent Disease Progression and Unusual MRI Findings
title_fullStr IgLON 5 Antibody Syndrome: Isolated Case of a Patient With Indolent Disease Progression and Unusual MRI Findings
title_full_unstemmed IgLON 5 Antibody Syndrome: Isolated Case of a Patient With Indolent Disease Progression and Unusual MRI Findings
title_short IgLON 5 Antibody Syndrome: Isolated Case of a Patient With Indolent Disease Progression and Unusual MRI Findings
title_sort iglon 5 antibody syndrome: isolated case of a patient with indolent disease progression and unusual mri findings
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971709/
https://www.ncbi.nlm.nih.gov/pubmed/33754109
http://dx.doi.org/10.7759/cureus.13386
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