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Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases
The function of Sprouty2 (Spry2) in T cells is unknown. Using 2 different (inducible and T cell–targeted) knockout mouse strains, we found that Spry2 positively regulated extracellular signal-regulated kinase 1/2 (ERK1/2) signaling by modulating the activity of LCK. Spry2(−/−) CD4(+) T cells were un...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971865/ https://www.ncbi.nlm.nih.gov/pubmed/33684096 http://dx.doi.org/10.1371/journal.pbio.3001063 |