Cargando…
Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch
PURPOSE: Wall shear stress (WSS) and pulse wave velocity (PWV) are important parameters to characterize blood flow in the vessel wall. Their quantification with flow-sensitive phase-contrast (PC) cardiovascular magnetic resonance (CMR), however, is time-consuming. Furthermore, the measurement of WSS...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972216/ https://www.ncbi.nlm.nih.gov/pubmed/33731147 http://dx.doi.org/10.1186/s12968-021-00725-4 |
_version_ | 1783666681301696512 |
---|---|
author | Winter, Patrick Andelovic, Kristina Kampf, Thomas Hansmann, Jan Jakob, Peter Michael Bauer, Wolfgang Rudolf Zernecke, Alma Herold, Volker |
author_facet | Winter, Patrick Andelovic, Kristina Kampf, Thomas Hansmann, Jan Jakob, Peter Michael Bauer, Wolfgang Rudolf Zernecke, Alma Herold, Volker |
author_sort | Winter, Patrick |
collection | PubMed |
description | PURPOSE: Wall shear stress (WSS) and pulse wave velocity (PWV) are important parameters to characterize blood flow in the vessel wall. Their quantification with flow-sensitive phase-contrast (PC) cardiovascular magnetic resonance (CMR), however, is time-consuming. Furthermore, the measurement of WSS requires high spatial resolution, whereas high temporal resolution is necessary for PWV measurements. For these reasons, PWV and WSS are challenging to measure in one CMR session, making it difficult to directly compare these parameters. By using a retrospective approach with a flexible reconstruction framework, we here aimed to simultaneously assess both PWV and WSS in the murine aortic arch from the same 4D flow measurement. METHODS: Flow was measured in the aortic arch of 18-week-old wildtype (n = 5) and ApoE(−/−) mice (n = 5) with a self-navigated radial 4D-PC-CMR sequence. Retrospective data analysis was used to reconstruct the same dataset either at low spatial and high temporal resolution (PWV analysis) or high spatial and low temporal resolution (WSS analysis). To assess WSS, the aortic lumen was labeled by semi-automatically segmenting the reconstruction with high spatial resolution. WSS was determined from the spatial velocity gradients at the lumen surface. For calculation of the PWV, segmentation data was interpolated along the temporal dimension. Subsequently, PWV was quantified from the through-plane flow data using the multiple-points transit-time method. Reconstructions with varying frame rates and spatial resolutions were performed to investigate the influence of spatiotemporal resolution on the PWV and WSS quantification. RESULTS: 4D flow measurements were conducted in an acquisition time of only 35 min. Increased peak flow and peak WSS values and lower errors in PWV estimation were observed in the reconstructions with high temporal resolution. Aortic PWV was significantly increased in ApoE(−/−) mice compared to the control group (1.7 ± 0.2 versus 2.6 ± 0.2 m/s, p < 0.001). Mean WSS magnitude values averaged over the aortic arch were (1.17 ± 0.07) N/m(2) in wildtype mice and (1.27 ± 0.10) N/m(2) in ApoE(−/−) mice. CONCLUSION: The post processing algorithm using the flexible reconstruction framework developed in this study permitted quantification of global PWV and 3D-WSS in a single acquisition. The possibility to assess both parameters in only 35 min will markedly improve the analyses and information content of in vivo measurements. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12968-021-00725-4. |
format | Online Article Text |
id | pubmed-7972216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-79722162021-03-19 Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch Winter, Patrick Andelovic, Kristina Kampf, Thomas Hansmann, Jan Jakob, Peter Michael Bauer, Wolfgang Rudolf Zernecke, Alma Herold, Volker J Cardiovasc Magn Reson Technical Notes PURPOSE: Wall shear stress (WSS) and pulse wave velocity (PWV) are important parameters to characterize blood flow in the vessel wall. Their quantification with flow-sensitive phase-contrast (PC) cardiovascular magnetic resonance (CMR), however, is time-consuming. Furthermore, the measurement of WSS requires high spatial resolution, whereas high temporal resolution is necessary for PWV measurements. For these reasons, PWV and WSS are challenging to measure in one CMR session, making it difficult to directly compare these parameters. By using a retrospective approach with a flexible reconstruction framework, we here aimed to simultaneously assess both PWV and WSS in the murine aortic arch from the same 4D flow measurement. METHODS: Flow was measured in the aortic arch of 18-week-old wildtype (n = 5) and ApoE(−/−) mice (n = 5) with a self-navigated radial 4D-PC-CMR sequence. Retrospective data analysis was used to reconstruct the same dataset either at low spatial and high temporal resolution (PWV analysis) or high spatial and low temporal resolution (WSS analysis). To assess WSS, the aortic lumen was labeled by semi-automatically segmenting the reconstruction with high spatial resolution. WSS was determined from the spatial velocity gradients at the lumen surface. For calculation of the PWV, segmentation data was interpolated along the temporal dimension. Subsequently, PWV was quantified from the through-plane flow data using the multiple-points transit-time method. Reconstructions with varying frame rates and spatial resolutions were performed to investigate the influence of spatiotemporal resolution on the PWV and WSS quantification. RESULTS: 4D flow measurements were conducted in an acquisition time of only 35 min. Increased peak flow and peak WSS values and lower errors in PWV estimation were observed in the reconstructions with high temporal resolution. Aortic PWV was significantly increased in ApoE(−/−) mice compared to the control group (1.7 ± 0.2 versus 2.6 ± 0.2 m/s, p < 0.001). Mean WSS magnitude values averaged over the aortic arch were (1.17 ± 0.07) N/m(2) in wildtype mice and (1.27 ± 0.10) N/m(2) in ApoE(−/−) mice. CONCLUSION: The post processing algorithm using the flexible reconstruction framework developed in this study permitted quantification of global PWV and 3D-WSS in a single acquisition. The possibility to assess both parameters in only 35 min will markedly improve the analyses and information content of in vivo measurements. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12968-021-00725-4. BioMed Central 2021-03-18 /pmc/articles/PMC7972216/ /pubmed/33731147 http://dx.doi.org/10.1186/s12968-021-00725-4 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Technical Notes Winter, Patrick Andelovic, Kristina Kampf, Thomas Hansmann, Jan Jakob, Peter Michael Bauer, Wolfgang Rudolf Zernecke, Alma Herold, Volker Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch |
title | Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch |
title_full | Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch |
title_fullStr | Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch |
title_full_unstemmed | Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch |
title_short | Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch |
title_sort | simultaneous measurements of 3d wall shear stress and pulse wave velocity in the murine aortic arch |
topic | Technical Notes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972216/ https://www.ncbi.nlm.nih.gov/pubmed/33731147 http://dx.doi.org/10.1186/s12968-021-00725-4 |
work_keys_str_mv | AT winterpatrick simultaneousmeasurementsof3dwallshearstressandpulsewavevelocityinthemurineaorticarch AT andelovickristina simultaneousmeasurementsof3dwallshearstressandpulsewavevelocityinthemurineaorticarch AT kampfthomas simultaneousmeasurementsof3dwallshearstressandpulsewavevelocityinthemurineaorticarch AT hansmannjan simultaneousmeasurementsof3dwallshearstressandpulsewavevelocityinthemurineaorticarch AT jakobpetermichael simultaneousmeasurementsof3dwallshearstressandpulsewavevelocityinthemurineaorticarch AT bauerwolfgangrudolf simultaneousmeasurementsof3dwallshearstressandpulsewavevelocityinthemurineaorticarch AT zerneckealma simultaneousmeasurementsof3dwallshearstressandpulsewavevelocityinthemurineaorticarch AT heroldvolker simultaneousmeasurementsof3dwallshearstressandpulsewavevelocityinthemurineaorticarch |