The allosteric modulation of complement C5 by knob domain peptides

Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce high-affinity peptides, we previously isolated autonomous 3–6 kDa knob domains from bovine antibodies. Here, we show that binding of four kn...

Descripción completa

Detalles Bibliográficos
Autores principales: Macpherson, Alex, Laabei, Maisem, Ahdash, Zainab, Graewert, Melissa A, Birtley, James R, Schulze, Monika-Sarah ED, Crennell, Susan, Robinson, Sarah A, Holmes, Ben, Oleinikovas, Vladas, Nilsson, Per H, Snowden, James, Ellis, Victoria, Mollnes, Tom Eirik, Deane, Charlotte M, Svergun, Dmitri, Lawson, Alastair DG, van den Elsen, Jean MH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972453/
https://www.ncbi.nlm.nih.gov/pubmed/33570492
http://dx.doi.org/10.7554/eLife.63586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972453/
https://www.ncbi.nlm.nih.gov/pubmed/33570492
http://dx.doi.org/10.7554/eLife.63586

Ejemplares similares