Testosterone’s Role in COVID-19

COVID-19 consistently displays a higher mortality in males. This sex-specific difference in outcomes is seen not only in the current COVID-19 pandemic, but also in prior viral epidemics and pandemics. Sex hormones, such as testosterone, play a clear role in modulating the immune response, providing...

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Detalles Bibliográficos
Autores principales: Auerbach, Jeremy M., Khera, Mohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Expert Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972673/
https://www.ncbi.nlm.nih.gov/pubmed/33903045
http://dx.doi.org/10.1016/j.jsxm.2021.03.004
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author Auerbach, Jeremy M.
Khera, Mohit
author_facet Auerbach, Jeremy M.
Khera, Mohit
author_sort Auerbach, Jeremy M.
collection PubMed
description COVID-19 consistently displays a higher mortality in males. This sex-specific difference in outcomes is seen not only in the current COVID-19 pandemic, but also in prior viral epidemics and pandemics. Sex hormones, such as testosterone, play a clear role in modulating the immune response, providing a clue that may illuminate the underpinnings of these outcomes. Developing a deeper understanding of these epidemiological findings permits a more effective response to the disease. This article summarizes the sex-specific COVID-19 outcomes, the role of androgens in generating these outcomes, and the potential role of modifying testosterone levels as a form of treatment of COVID-19.
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spelling pubmed-79726732021-03-19 Testosterone’s Role in COVID-19 Auerbach, Jeremy M. Khera, Mohit J Sex Med Expert Opinion COVID-19 consistently displays a higher mortality in males. This sex-specific difference in outcomes is seen not only in the current COVID-19 pandemic, but also in prior viral epidemics and pandemics. Sex hormones, such as testosterone, play a clear role in modulating the immune response, providing a clue that may illuminate the underpinnings of these outcomes. Developing a deeper understanding of these epidemiological findings permits a more effective response to the disease. This article summarizes the sex-specific COVID-19 outcomes, the role of androgens in generating these outcomes, and the potential role of modifying testosterone levels as a form of treatment of COVID-19. Oxford University Press 2021-03-18 /pmc/articles/PMC7972673/ /pubmed/33903045 http://dx.doi.org/10.1016/j.jsxm.2021.03.004 Text en © 2021, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Expert Opinion
Auerbach, Jeremy M.
Khera, Mohit
Testosterone’s Role in COVID-19
title Testosterone’s Role in COVID-19
title_full Testosterone’s Role in COVID-19
title_fullStr Testosterone’s Role in COVID-19
title_full_unstemmed Testosterone’s Role in COVID-19
title_short Testosterone’s Role in COVID-19
title_sort testosterone’s role in covid-19
topic Expert Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972673/
https://www.ncbi.nlm.nih.gov/pubmed/33903045
http://dx.doi.org/10.1016/j.jsxm.2021.03.004
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