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A Simple-to-Use Nomogram for Predicting Survival in Children with Acute Myeloid Leukemia
BACKGROUND: The research analyzed a group of patients to develop a statistical nomogram and a web-based survival rate predictor for the comprehensive estimate of the overall survival (OS) of children with acute myeloid leukemia. METHODS: Between 1999 to 2015, we used the Therapeutically Applicable R...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972835/ https://www.ncbi.nlm.nih.gov/pubmed/33778082 http://dx.doi.org/10.1155/2021/7264623 |
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author | Jiang, Feng Yu, Xiang Wu, Chuyan Wang, Ming Wei, Ke Zhou, Guoping Wang, Jimei |
author_facet | Jiang, Feng Yu, Xiang Wu, Chuyan Wang, Ming Wei, Ke Zhou, Guoping Wang, Jimei |
author_sort | Jiang, Feng |
collection | PubMed |
description | BACKGROUND: The research analyzed a group of patients to develop a statistical nomogram and a web-based survival rate predictor for the comprehensive estimate of the overall survival (OS) of children with acute myeloid leukemia. METHODS: Between 1999 to 2015, we used the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database to evaluate and randomly divide 440 children diagnosed with AML into the population of training (n = 309) and validation (n = 131). The analysis of Lasso Cox was used to identify separate predictive variables. We have used essential forecasting considerations to construct a nomogram and a web-based calculator focused on Cox regression analysis. Nomogram validation was tested through discrimination and calibration. RESULTS: Compared to the multivariate training cohort models, a nomogram integrating gender, age of diagnose, WBC at diagnosis, bone marrow leukemic blast percentage, and chromosomal abnormalities [t(8; 21), inv(16)] were designed for the prediction of OS. We also developed a predictive survival nomogram and a web-based calculator. C-indexes validated internally and checked externally were 0.747 and 0.716. The calibration curves have shown that the nomogram might accurately forecast 3-year and 5-year OS. CONCLUSIONS: A nomogram effectively predicts survival in children with AML. This prognostic model can be used in clinical practice. |
format | Online Article Text |
id | pubmed-7972835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-79728352021-03-26 A Simple-to-Use Nomogram for Predicting Survival in Children with Acute Myeloid Leukemia Jiang, Feng Yu, Xiang Wu, Chuyan Wang, Ming Wei, Ke Zhou, Guoping Wang, Jimei Biomed Res Int Research Article BACKGROUND: The research analyzed a group of patients to develop a statistical nomogram and a web-based survival rate predictor for the comprehensive estimate of the overall survival (OS) of children with acute myeloid leukemia. METHODS: Between 1999 to 2015, we used the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database to evaluate and randomly divide 440 children diagnosed with AML into the population of training (n = 309) and validation (n = 131). The analysis of Lasso Cox was used to identify separate predictive variables. We have used essential forecasting considerations to construct a nomogram and a web-based calculator focused on Cox regression analysis. Nomogram validation was tested through discrimination and calibration. RESULTS: Compared to the multivariate training cohort models, a nomogram integrating gender, age of diagnose, WBC at diagnosis, bone marrow leukemic blast percentage, and chromosomal abnormalities [t(8; 21), inv(16)] were designed for the prediction of OS. We also developed a predictive survival nomogram and a web-based calculator. C-indexes validated internally and checked externally were 0.747 and 0.716. The calibration curves have shown that the nomogram might accurately forecast 3-year and 5-year OS. CONCLUSIONS: A nomogram effectively predicts survival in children with AML. This prognostic model can be used in clinical practice. Hindawi 2021-03-11 /pmc/articles/PMC7972835/ /pubmed/33778082 http://dx.doi.org/10.1155/2021/7264623 Text en Copyright © 2021 Feng Jiang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Jiang, Feng Yu, Xiang Wu, Chuyan Wang, Ming Wei, Ke Zhou, Guoping Wang, Jimei A Simple-to-Use Nomogram for Predicting Survival in Children with Acute Myeloid Leukemia |
title | A Simple-to-Use Nomogram for Predicting Survival in Children with Acute Myeloid Leukemia |
title_full | A Simple-to-Use Nomogram for Predicting Survival in Children with Acute Myeloid Leukemia |
title_fullStr | A Simple-to-Use Nomogram for Predicting Survival in Children with Acute Myeloid Leukemia |
title_full_unstemmed | A Simple-to-Use Nomogram for Predicting Survival in Children with Acute Myeloid Leukemia |
title_short | A Simple-to-Use Nomogram for Predicting Survival in Children with Acute Myeloid Leukemia |
title_sort | simple-to-use nomogram for predicting survival in children with acute myeloid leukemia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972835/ https://www.ncbi.nlm.nih.gov/pubmed/33778082 http://dx.doi.org/10.1155/2021/7264623 |
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