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Clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs

Urethral sphincter mechanism incompetence (USMI) is a common cause of urinary incontinence in dogs. Although estrogen is often prescribed for the medical therapy of USMI for spayed female dogs, they are known to have limited effectiveness and potential adverse effects. In castrated male dogs with US...

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Autores principales: NISHI, Reo, MOTEGI, Tomoki, MAEDA, Shingo, TAMAHARA, Satoshi, MOMOI, Yasuyuki, MATSUKI, Naoaki, YONEZAWA, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972894/
https://www.ncbi.nlm.nih.gov/pubmed/33441521
http://dx.doi.org/10.1292/jvms.20-0515
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author NISHI, Reo
MOTEGI, Tomoki
MAEDA, Shingo
TAMAHARA, Satoshi
MOMOI, Yasuyuki
MATSUKI, Naoaki
YONEZAWA, Tomohiro
author_facet NISHI, Reo
MOTEGI, Tomoki
MAEDA, Shingo
TAMAHARA, Satoshi
MOMOI, Yasuyuki
MATSUKI, Naoaki
YONEZAWA, Tomohiro
author_sort NISHI, Reo
collection PubMed
description Urethral sphincter mechanism incompetence (USMI) is a common cause of urinary incontinence in dogs. Although estrogen is often prescribed for the medical therapy of USMI for spayed female dogs, they are known to have limited effectiveness and potential adverse effects. In castrated male dogs with USMI, testosterone reagents have been attempted besides estrogen. In this study, the effect of testosterone drugs, mainly methyltestosterone, on spayed female dogs with USMI was retrospectively evaluated. Ten spayed female dogs with USMI were included. Diagnosis of USMI was based on the results of the dogs’ medical history, clinical signs, and no abnormalities in physical examinations, urinalysis, ultrasonography, X-ray imaging, and neurological examinations. Methyltestosterone was administered at doses of 0.32–1.27 mg/kg BW p.o. semel in die (sid.) to twice a week. Nine of the ten dogs had good or excellent responses 2 to 4 weeks after the start of treatment. The minimum effective dose was 0.32 mg/kg/day. Although no severe adverse symptoms occurred in any dog, a mild increase in alanine aminotransferase was temporally observed at doses of 1.0 and 1.1 mg/kg/day in the two dogs. After dose reduction or withdrawal, two of eight dogs had recurrence of urinary incontinence. Resumption of testosterone treatment clearly improved the symptoms in the two dogs. These results indicate that testosterone reagents might be an option for treating USMI in spayed female dogs as well.
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spelling pubmed-79728942021-03-23 Clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs NISHI, Reo MOTEGI, Tomoki MAEDA, Shingo TAMAHARA, Satoshi MOMOI, Yasuyuki MATSUKI, Naoaki YONEZAWA, Tomohiro J Vet Med Sci Internal Medicine Urethral sphincter mechanism incompetence (USMI) is a common cause of urinary incontinence in dogs. Although estrogen is often prescribed for the medical therapy of USMI for spayed female dogs, they are known to have limited effectiveness and potential adverse effects. In castrated male dogs with USMI, testosterone reagents have been attempted besides estrogen. In this study, the effect of testosterone drugs, mainly methyltestosterone, on spayed female dogs with USMI was retrospectively evaluated. Ten spayed female dogs with USMI were included. Diagnosis of USMI was based on the results of the dogs’ medical history, clinical signs, and no abnormalities in physical examinations, urinalysis, ultrasonography, X-ray imaging, and neurological examinations. Methyltestosterone was administered at doses of 0.32–1.27 mg/kg BW p.o. semel in die (sid.) to twice a week. Nine of the ten dogs had good or excellent responses 2 to 4 weeks after the start of treatment. The minimum effective dose was 0.32 mg/kg/day. Although no severe adverse symptoms occurred in any dog, a mild increase in alanine aminotransferase was temporally observed at doses of 1.0 and 1.1 mg/kg/day in the two dogs. After dose reduction or withdrawal, two of eight dogs had recurrence of urinary incontinence. Resumption of testosterone treatment clearly improved the symptoms in the two dogs. These results indicate that testosterone reagents might be an option for treating USMI in spayed female dogs as well. The Japanese Society of Veterinary Science 2021-01-14 2021-02 /pmc/articles/PMC7972894/ /pubmed/33441521 http://dx.doi.org/10.1292/jvms.20-0515 Text en ©2021 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Internal Medicine
NISHI, Reo
MOTEGI, Tomoki
MAEDA, Shingo
TAMAHARA, Satoshi
MOMOI, Yasuyuki
MATSUKI, Naoaki
YONEZAWA, Tomohiro
Clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs
title Clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs
title_full Clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs
title_fullStr Clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs
title_full_unstemmed Clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs
title_short Clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs
title_sort clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972894/
https://www.ncbi.nlm.nih.gov/pubmed/33441521
http://dx.doi.org/10.1292/jvms.20-0515
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