Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice

Fipronil (FPN) is a systemic insecticide that antagonizes the gamma-aminobutyric acid type A (GABA(A)) receptors in insects. Recently, adverse effects of FPN on mammals have been reported, but most of those were caused by high doses of FPN and additives in the products. We investigated the effects o...

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Autores principales: MAEDA, Mizuki, YOKOYAMA, Toshifumi, KITAUCHI, Sayaka, HIRANO, Tetsushi, MANTANI, Youhei, TABUCHI, Yoshiaki, HOSHI, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2020
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972900/
https://www.ncbi.nlm.nih.gov/pubmed/33361683
http://dx.doi.org/10.1292/jvms.20-0551
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author MAEDA, Mizuki
YOKOYAMA, Toshifumi
KITAUCHI, Sayaka
HIRANO, Tetsushi
MANTANI, Youhei
TABUCHI, Yoshiaki
HOSHI, Nobuhiko
author_facet MAEDA, Mizuki
YOKOYAMA, Toshifumi
KITAUCHI, Sayaka
HIRANO, Tetsushi
MANTANI, Youhei
TABUCHI, Yoshiaki
HOSHI, Nobuhiko
author_sort MAEDA, Mizuki
collection PubMed
description Fipronil (FPN) is a systemic insecticide that antagonizes the gamma-aminobutyric acid type A (GABA(A)) receptors in insects. Recently, adverse effects of FPN on mammals have been reported, but most of those were caused by high doses of FPN and additives in the products. We investigated the effects of low-dose pure FPN on the emotional behavior of mice. Nine-week-old male mice conducted behavioral tests 24 hr after FPN administration by gavage at doses of 0.05 or 5 mg/kg based on the no-observed-effect level (NOEL), showed a significant increase in locomotor activity and dose-dependent responses on the time they spent in the central zone in the open field test. Pure FPN below the NOEL dose may affect the emotional behavior of mice.
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spelling pubmed-79729002021-03-23 Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice MAEDA, Mizuki YOKOYAMA, Toshifumi KITAUCHI, Sayaka HIRANO, Tetsushi MANTANI, Youhei TABUCHI, Yoshiaki HOSHI, Nobuhiko J Vet Med Sci Toxicology Fipronil (FPN) is a systemic insecticide that antagonizes the gamma-aminobutyric acid type A (GABA(A)) receptors in insects. Recently, adverse effects of FPN on mammals have been reported, but most of those were caused by high doses of FPN and additives in the products. We investigated the effects of low-dose pure FPN on the emotional behavior of mice. Nine-week-old male mice conducted behavioral tests 24 hr after FPN administration by gavage at doses of 0.05 or 5 mg/kg based on the no-observed-effect level (NOEL), showed a significant increase in locomotor activity and dose-dependent responses on the time they spent in the central zone in the open field test. Pure FPN below the NOEL dose may affect the emotional behavior of mice. The Japanese Society of Veterinary Science 2020-12-22 2021-02 /pmc/articles/PMC7972900/ /pubmed/33361683 http://dx.doi.org/10.1292/jvms.20-0551 Text en ©2021 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Toxicology
MAEDA, Mizuki
YOKOYAMA, Toshifumi
KITAUCHI, Sayaka
HIRANO, Tetsushi
MANTANI, Youhei
TABUCHI, Yoshiaki
HOSHI, Nobuhiko
Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice
title Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice
title_full Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice
title_fullStr Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice
title_full_unstemmed Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice
title_short Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice
title_sort influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice
topic Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972900/
https://www.ncbi.nlm.nih.gov/pubmed/33361683
http://dx.doi.org/10.1292/jvms.20-0551
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