Weight Loss Intervention before Cord Blood Transplantation in an Obese Patient with Acute Myeloid Leukemia: A Case Study

BACKGROUND: A severely obese woman (39.8 kg/m(2)) with relapsed acute myeloid leukemia was admitted to our hospital to undergo salvage chemotherapy followed by cord blood transplantation (CBT). CASE: During the salvage chemotherapy period, a 70-day weight loss program addressing diet and exercise wa...

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Detalles Bibliográficos
Autores principales: Kasahara, Ryuichi, Fujita, Takaaki, Jinbo, Ryohei, Kai, Tatsuyuki, Yamamoto, Yuichi, Morishita, Shinichiro, Furukawa, Miki, Shiga, Yutaka, Kimura, Hideo, Fukatsu, Masahiko, Harada, Kayo, Kimura, Satoshi, Ikezoe, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JARM 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972948/
https://www.ncbi.nlm.nih.gov/pubmed/33768187
http://dx.doi.org/10.2490/prm.20210018
Descripción
Sumario:BACKGROUND: A severely obese woman (39.8 kg/m(2)) with relapsed acute myeloid leukemia was admitted to our hospital to undergo salvage chemotherapy followed by cord blood transplantation (CBT). CASE: During the salvage chemotherapy period, a 70-day weight loss program addressing diet and exercise was administered. After the 70-day intervention, the patient’s body weight and body fat mass had decreased (8.6% and 15.0%, respectively) without any adverse events. The number of available cord blood units with total nucleated cells per body weight greater than 2 × 10(7)/kg was zero at admission and two after weight loss; therefore, CBT could be performed. DISCUSSION: Considering this case, we suggest that a weight loss program combining exercise and nutrition therapy may help patients scheduled for hematopoietic stem cell transplantation by focusing on risk management.

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