COX2 regulates senescence secretome composition and senescence surveillance through PGE(2)

Senescent cells trigger their own immune-mediated destruction, termed senescence surveillance. This is dependent on the inflammatory senescence-associated secretory phenotype (SASP), which includes COX2, an enzyme with complex roles in cancer. The role COX2 plays during senescence surveillance is un...

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Detalles Bibliográficos
Autores principales: Gonçalves, Susana, Yin, Kelvin, Ito, Yoko, Chan, Adelyne, Olan, Ioana, Gough, Sarah, Cassidy, Liam, Serrao, Eva, Smith, Stephen, Young, Andrew, Narita, Masashi, Hoare, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972992/
https://www.ncbi.nlm.nih.gov/pubmed/33730589
http://dx.doi.org/10.1016/j.celrep.2021.108860

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