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COX2 regulates senescence secretome composition and senescence surveillance through PGE(2)
Senescent cells trigger their own immune-mediated destruction, termed senescence surveillance. This is dependent on the inflammatory senescence-associated secretory phenotype (SASP), which includes COX2, an enzyme with complex roles in cancer. The role COX2 plays during senescence surveillance is un...
Autores principales: | Gonçalves, Susana, Yin, Kelvin, Ito, Yoko, Chan, Adelyne, Olan, Ioana, Gough, Sarah, Cassidy, Liam, Serrao, Eva, Smith, Stephen, Young, Andrew, Narita, Masashi, Hoare, Matthew |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972992/ https://www.ncbi.nlm.nih.gov/pubmed/33730589 http://dx.doi.org/10.1016/j.celrep.2021.108860 |
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